Design of Simulated Moving Bed Chromatography - CPAC

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Features of Versatile SMB • Dedicated valves and manifolds for high purity and high yield • Allows zone bypass, open loop, multizone, multisolvent ,and multicomponent separation. • Easy column expansibility. • Moving port chromatography. • Online decoupled regeneration (Animation) • Independent column switching for variable step time
Knowledge-Based Design & Optimization Engineering Parameters Mobile Phase, pH, Stationary Phase, Temperature Process Design & Optimization VERSE Simulator Experimental Verification Batch or V-SMB Exp Solubility, Capacity, Selectivity Elution Profile, Purity, Yield, Concentration, Productivity Elution Profile, Purity, Yield, Concentration, Productivity Pulse, Frontal Voidage, Isotherm, Mass Transfer, Numerical Parameters SWD, Scale-Up, Optimization Sensitivity, Trade-off Optimal Design Optimal Process (Hirtzko et al., 1999; Mun et al., 2005; Wu et al., 1997; Xie et al., 2002)
Page 1 and 2: Simulated Moving Bed Chromatography
Page 3 and 4: CONVENTIONAL CHROMATOGRAPHY A Batch
Page 5 and 6: Mechanisms of Adsorption
Page 7 and 8: Solution I- Binary Separation in a
Page 9 and 10: Advantages of SMB over Batch • On
Page 11 and 12: Key Barriers in SMB • A four-zone
Page 13 and 14: Conc. Standing Wave Design: Binary,
Page 15 and 16: Concentration Standing Wave Design:
Page 17 and 18: VErsatile Reaction SEparation Simul
Page 19: Versatile SMB To implement complex
Page 23 and 24: Knowledge-Based Design of Tandem SM
Page 25 and 26: Conventional Size Exclusion Chromat
Page 27 and 28: SMB Experimental Validation : Ring
Page 29 and 30: Parameter (5,000 kg insulin / year)
Page 31 and 32: Design & Optimization (Mun et al.,
Page 33: Acknowledgements • Eli Lilly Co.

Design of Simulated Moving Bed Chromatography - CPAC

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