Design of Simulated Moving Bed Chromatography - CPAC

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VERSE VErsatile Reaction SEparation Simulator • Simulation based on a detailed dynamic rate model (transient differential mass balances) • Thousands of equations solved at each instance • To predict column profiles and histories • To understand transient phenomena in batch chromatography, carousel, and SMB • To understand residence time and batch integrity issues in SMB • To reduce the number of costly experiments
Versatile SMB To implement complex processes for multicomponent separations Valve Controls Valves Sephadex G50 Columns Pumps
Page 1 and 2: Simulated Moving Bed Chromatography
Page 3 and 4: CONVENTIONAL CHROMATOGRAPHY A Batch
Page 5 and 6: Mechanisms of Adsorption
Page 7 and 8: Solution I- Binary Separation in a
Page 9 and 10: Advantages of SMB over Batch • On
Page 11 and 12: Key Barriers in SMB • A four-zone
Page 13 and 14: Conc. Standing Wave Design: Binary,
Page 15 and 16: Concentration Standing Wave Design:
Page 17: VErsatile Reaction SEparation Simul
Page 21 and 22: Knowledge-Based Design & Optimizati
Page 23 and 24: Knowledge-Based Design of Tandem SM
Page 25 and 26: Conventional Size Exclusion Chromat
Page 27 and 28: SMB Experimental Validation : Ring
Page 29 and 30: Parameter (5,000 kg insulin / year)
Page 31 and 32: Design & Optimization (Mun et al.,
Page 33: Acknowledgements • Eli Lilly Co.

Design of Simulated Moving Bed Chromatography - CPAC

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