Design of Simulated Moving Bed Chromatography - CPAC

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Solution II–Moving Port or SMB Desorbent 1 ZONE I 2 Extract 8 Solute Movement 3 ZONE IV 7 Step N ZONE III 4 ZONE II Raffinate 6 5 Feed
Advantages of SMB over Batch • Only partial separation of solutes is required to obtain high purity. • Higher yield than batch – 10% more than batch. • High purity achievable without sacrificing yield. • High productivity– 5 to 10 fold increase. • Less solvent – 5 to 10 fold less. • Reduced environment impact. • Reduced footprint, equipment size, and manpower. • Continuous process-high throughput. • Economical for large scale separations.
Page 1 and 2: Simulated Moving Bed Chromatography
Page 3 and 4: CONVENTIONAL CHROMATOGRAPHY A Batch
Page 5 and 6: Mechanisms of Adsorption
Page 7: Solution I- Binary Separation in a
Page 11 and 12: Key Barriers in SMB • A four-zone
Page 13 and 14: Conc. Standing Wave Design: Binary,
Page 15 and 16: Concentration Standing Wave Design:
Page 17 and 18: VErsatile Reaction SEparation Simul
Page 19 and 20: Versatile SMB To implement complex
Page 21 and 22: Knowledge-Based Design & Optimizati
Page 23 and 24: Knowledge-Based Design of Tandem SM
Page 25 and 26: Conventional Size Exclusion Chromat
Page 27 and 28: SMB Experimental Validation : Ring
Page 29 and 30: Parameter (5,000 kg insulin / year)
Page 31 and 32: Design & Optimization (Mun et al.,
Page 33: Acknowledgements • Eli Lilly Co.

Design of Simulated Moving Bed Chromatography - CPAC

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