Design of Simulated Moving Bed Chromatography - CPAC
Design of Simulated Moving Bed Chromatography - CPAC
Design of Simulated Moving Bed Chromatography - CPAC
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Parameter (5,000 kg insulin /<br />
year)<br />
Batch Xie (2002) Overall Optimized SMB<br />
Overall Yield (%) 89 99 99<br />
Column<br />
Configuration<br />
Ring A<br />
2-2-4-2 2-2-4-2<br />
12 in series<br />
Ring B 2-3-3-2 2-2-2-2<br />
Feed Flowrate (mL/min) 11 (each) 115 115<br />
Column Length (cm)<br />
Diameter (cm)<br />
Ring A<br />
13.7 9.34<br />
15<br />
Ring B 13.7 7.02<br />
Ring A 45<br />
47.9 27.2<br />
Ring B (12 units) 58.6 42.6<br />
Throughput (L/h/100 L BV) .23 1.19 5.36<br />
Solv. consumption (L/kg insulin) 150 42 55.6<br />
Equip. Cost ($/kg insulin) 35.71 29.76 29.17<br />
Solv. Cost ($/kg insulin) 15 4.20 5.56<br />
Resin Cost ($/kg insulin) 40.07 7.41 1.61<br />
Total Cost ($/kg) 90.78 41.50 36.35
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