Design of Simulated Moving Bed Chromatography - CPAC
Design of Simulated Moving Bed Chromatography - CPAC
Design of Simulated Moving Bed Chromatography - CPAC
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Knowledge-Based <strong>Design</strong> & Optimization<br />
Engineering<br />
Parameters<br />
Mobile Phase, pH,<br />
Stationary Phase,<br />
Temperature<br />
Process <strong>Design</strong> &<br />
Optimization<br />
VERSE<br />
Simulator<br />
Experimental<br />
Verification<br />
Batch or<br />
V-SMB Exp<br />
Solubility,<br />
Capacity,<br />
Selectivity<br />
Elution Pr<strong>of</strong>ile,<br />
Purity, Yield,<br />
Concentration,<br />
Productivity<br />
Elution Pr<strong>of</strong>ile,<br />
Purity, Yield,<br />
Concentration,<br />
Productivity<br />
Pulse,<br />
Frontal<br />
Voidage,<br />
Isotherm,<br />
Mass Transfer,<br />
Numerical<br />
Parameters<br />
SWD,<br />
Scale-Up,<br />
Optimization<br />
Sensitivity,<br />
Trade-<strong>of</strong>f<br />
Optimal<br />
<strong>Design</strong><br />
Optimal<br />
Process<br />
(Hirtzko et al., 1999; Mun et al., 2005; Wu et al., 1997; Xie et al., 2002)