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Design of Simulated Moving Bed Chromatography - CPAC

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Knowledge-Based <strong>Design</strong> & Optimization<br />

Engineering<br />

Parameters<br />

Mobile Phase, pH,<br />

Stationary Phase,<br />

Temperature<br />

Process <strong>Design</strong> &<br />

Optimization<br />

VERSE<br />

Simulator<br />

Experimental<br />

Verification<br />

Batch or<br />

V-SMB Exp<br />

Solubility,<br />

Capacity,<br />

Selectivity<br />

Elution Pr<strong>of</strong>ile,<br />

Purity, Yield,<br />

Concentration,<br />

Productivity<br />

Elution Pr<strong>of</strong>ile,<br />

Purity, Yield,<br />

Concentration,<br />

Productivity<br />

Pulse,<br />

Frontal<br />

Voidage,<br />

Isotherm,<br />

Mass Transfer,<br />

Numerical<br />

Parameters<br />

SWD,<br />

Scale-Up,<br />

Optimization<br />

Sensitivity,<br />

Trade-<strong>of</strong>f<br />

Optimal<br />

<strong>Design</strong><br />

Optimal<br />

Process<br />

(Hirtzko et al., 1999; Mun et al., 2005; Wu et al., 1997; Xie et al., 2002)

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