Design of Simulated Moving Bed Chromatography - CPAC
Design of Simulated Moving Bed Chromatography - CPAC
Design of Simulated Moving Bed Chromatography - CPAC
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SMB Experimental Validation: Ring II<br />
C/CF<br />
1<br />
0.8<br />
0.6<br />
0.4<br />
0.2<br />
0<br />
(b) Effluent histories at the extract port<br />
0 20 40 60<br />
Switching Step<br />
Insulin exp.<br />
Insulin sim.<br />
ZnCl2 exp.<br />
ZnCl2 sim.<br />
(c) Mid-step column pr<strong>of</strong>iles at cyclic steady state<br />
Desorbent Extract Feed Raffinate<br />
1.2<br />
Zone I<br />
Zone II<br />
Zone III<br />
Zone IV<br />
C/CF<br />
0.9<br />
0.6<br />
0.3<br />
Insulin exp.<br />
Insulin sim.<br />
ZnCl2 exp.<br />
ZnCl2 sim.<br />
0<br />
0 1 2 3 4 5 6 7 8 9 10<br />
Column number
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