Design of Simulated Moving Bed Chromatography - CPAC

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Overview • Chromatography and SMB – Principles – Key Barriers • Purdue SMB Technologies – Standing Wave Design & Optimization – VERSE Dynamic Simulations – Versatile SMB Equipment (V SMB) – Knowledge- Based Design Method • Examples – Tandem SMB for insulin purification – Five-zone SMB to recover six sugars from biomass hydrolysate
CONVENTIONAL CHROMATOGRAPHY A Batch Process Eluent Feed Pre-equilibration Adsorbent Particles 3
Page 1: Simulated Moving Bed Chromatography
Page 5 and 6: Mechanisms of Adsorption
Page 7 and 8: Solution I- Binary Separation in a
Page 9 and 10: Advantages of SMB over Batch • On
Page 11 and 12: Key Barriers in SMB • A four-zone
Page 13 and 14: Conc. Standing Wave Design: Binary,
Page 15 and 16: Concentration Standing Wave Design:
Page 17 and 18: VErsatile Reaction SEparation Simul
Page 19 and 20: Versatile SMB To implement complex
Page 21 and 22: Knowledge-Based Design & Optimizati
Page 23 and 24: Knowledge-Based Design of Tandem SM
Page 25 and 26: Conventional Size Exclusion Chromat
Page 27 and 28: SMB Experimental Validation : Ring
Page 29 and 30: Parameter (5,000 kg insulin / year)
Page 31 and 32: Design & Optimization (Mun et al.,
Page 33: Acknowledgements • Eli Lilly Co.

Design of Simulated Moving Bed Chromatography - CPAC

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