Design of Simulated Moving Bed Chromatography - CPAC
Design of Simulated Moving Bed Chromatography - CPAC
Design of Simulated Moving Bed Chromatography - CPAC
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Conc.<br />
Standing Wave <strong>Design</strong>- Linear, Non-ideal Systems<br />
Desorbent<br />
Desorption wave <strong>of</strong> Low affinity<br />
solute confined in Zone II<br />
Feed<br />
Adsorption wave <strong>of</strong> Low affinity<br />
solute confined in Zone IV<br />
Zone I Zone II Zone III Zone IV<br />
Extract<br />
<strong>Bed</strong> Position<br />
Raffinate<br />
•Ideal System: Matching wave velocities with port<br />
velocity to ensure high purity and yield<br />
•Non-ideal Systems: Difference in wave velocity and<br />
port velocity allows wave focusing in each zone
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