Design of Simulated Moving Bed Chromatography - CPAC
Design of Simulated Moving Bed Chromatography - CPAC
Design of Simulated Moving Bed Chromatography - CPAC
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Conventional Size Exclusion <strong>Chromatography</strong><br />
1<br />
0.8<br />
Insulin<br />
(Product)<br />
C/CF<br />
0.6<br />
0.4<br />
Proinsulin /<br />
HMWP<br />
Fronting<br />
Zinc<br />
Chloride<br />
0.2<br />
0<br />
Proinsulin / HMWP<br />
Insulin (Product)<br />
Zinc Chloride<br />
Animation<br />
0 100 200 300<br />
Volume (L)<br />
BHI exp. HPI exp. HPI sim.<br />
• Existing SEC batch process<br />
ZnCl2 exp. BHI sim. ZnCl2 sim.<br />
• Yield < 90%<br />
• Purity >99%<br />
• Resin throughput = 0.23 L / hr/100 L BV
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