3dT4E4Rnm

Chapter 6. Step Two, Part One
Again, more detail will follow the material on the mutations.
Overview of the Mutations
First and Second Priority Mutations
SHMT and/or ACAT mutations: Consider addressing these first if you or your
child have any of the following test results: elevated iron on a UEE test, Short
Chain Fatty Acid (SCFA) imbalances on a CSA test, suberic, beta hydroxyl
methylglutaric acid, or other ketone and fatty acid metabolites imbalances on a
MAP or OAT test; or if there are severe gut issues or muscle weakness (which
can be related to aluminum retention)
CBS mutations: Unless these are addressed first, adding in other methylation
cycle supports can lead to increased levels of ammonia, highly elevated taurine,
hydrogen sulfide, and other toxic sulfur byproducts. We address these via the
Ammonia Program (see below.)
Address the rest of the methylation cycle imbalances by supporting both the
“long way” around the cycle via the MTR/MTRR as well as the “shortcut”
through the cycle via the BHMT enzyme.
Prior to beginning Step Two, you may also wish to run an initial, baseline urine
amino acid (UAA) a MAP (or OAT) and CSA tests. When looking at these
tests in conjunction with the Nutrigenomic test you can refine the supplement
choices for you or your child.
First Priority Mutations
Addressing SHMT and ACAT Mutations
People with the SHMT and/or ACAT mutations sometimes have a greater tendency
to experience gut dysbiosis and imbalanced flora. Until the flora are balanced,
there’s a risk that the undesirable microbes will retain toxic metals. So, for
those with ACAT or SHMT as well as other mutations (such as the MTHFR
A1298C) that confer a greater likelihood of retaining aluminum, it is essential,
prior to addressing these other mutations, to first stabilize the general gut environment
via SHMT and/or ACAT support, by using supplements in the MPA
received with your test results.
If both SHMT+ and ACAT + are present, begin with SHMT support first, and
once that is in place, layer in ACAT support.
Understanding SHMT Mutations
Based on the research of Dr. Patrick Stover, I’ve concluded that the SHMT
mutation often shifts the methylation cycle away from both the long and short
routes through the methylation cycle into a side reaction that leads to the production
of thymidine (see illustration.)
Autism: Pathways to Recovery
127