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Chapter 2. Nutrigenomics and the Methylation Cycle<br />

makes the methylation cycle so unique and so critical for health is that mutations<br />

in this pathway can have an impact on all of these factors. This concept is so important<br />

that I will repeat it, just to be sure you have gotten the message:<br />

Autism is a multifactorial condition, with genetic,<br />

infectious, and environmental contributors.<br />

What makes the methylation cycle so unique and so critical for health is that<br />

mutations in this pathway can have an impact on all of these factors. Picture each<br />

mutation as an accident causing a traffic tie-up. One accident will slow down the<br />

flow of vehicles on the highway. A second or third will snarl things even more.<br />

Through targeted supplementation, we are in effect creating a way for a vehicle<br />

to bypass the sites where the accidents have occurred, take a detour, and move<br />

further toward its destination. In the case of the methylation highway, these bypasses<br />

permit us to move beyond the blockades caused by mutations to produce<br />

and deliver the methyl groups that are key to a wide range of bodily functions.<br />

Each methyl group consists of a carbon atom bonded to three hydrogen atoms,<br />

CH3. But since a carbon atom can bond with four other atoms, each methyl<br />

group has one more available bond, which constantly attaches to and detaches<br />

from numerous other molecules in the process known as methylation.<br />

Autism: Pathways to Recovery<br />

27

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