3dT4E4Rnm

Tracking Detoxification
What levels of B12 support are needed That depends on the individual—and
the Urine Essential Elements Test (UEE) can help you to make that determination.
Once the cobalt levels found on the UEE are shown as a black line across
the test results page, then you have attained the right level of B12 support. You
should continue to supplement to maintain that level, while also beginning to
introduce additional support to help with oxidized species. Trehalose, spirulina,
quercetin, riboflavin, NADH, and ATP are all good for that purpose. On subsequent
UEE tests, even as you continue to supplement the same high concentrations
of B12, look out for this important indicator: When the cobalt levels drop
back to baseline, as you maintain high level B12 support, this is when there are
often major increases in excretion. As you can see, it’s important to follow this
process with regular UTM/ UEE testing and to work in conjunction with your
doctor on the detoxification process.
MTHFR Status
Understanding MTHFR C677T +
When it comes to autism recovery, I find this to be a less severe mutation than
the other MTHFR mutation, MTHFR A1298C. However, the C677T mutation
impacts the body’s ability to convert homocysteine to methionine, leading
to increased levels of homocysteine. High homocysteine levels have been associated
with heart disease, Alzheimer’s disease, and a range of other inflammatory
diseases, including vascular inflammation, and “thick blood,” which can lead to
hyper-coagulation and inflammation.
High Homocysteine and SAH
With high homocysteine levels, S adenosyl homocysteine (SAH) accumulates
in the body, inhibiting several enzymes in the methylation pathway, including
the COMT enzyme discussed earlier in this chapter. While inhibiting COMT
can increase dopamine levels for those with COMT V158M -/-, for people with
COMT V158M +/+, this very same action can lead to mood swings. SAH also
inhibits key enzymes that transfer methyl groups to DNA, RNA and proteins,
resulting in the inhibition of DNA methylation.
Addressing MTHFR C677T
Appropriate supplementation should help to alleviate these undesirable effects.
The C677T mutation serves the forward reaction of the MTHFR enzyme, reducing
the ability of the body to make a specific kind of folate called 5 methyl
folate. That’s why it’s important to supplement with this specific form of folate
148 Autism: Pathways to Recovery