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Chapter 6. Step Two, Part One • Increased ammonia • Until we support the methylation cycle, we are not going to see the full impact of the CBS upregulations. BH4 Supplementation Preliminary collaborative research is ongoing with a group of doctors in Japan looking at the use of prescription BH4 to help to compensate for MTHFR A1298C and CBS C699T+ mutations. The initial results are encouraging. Low daily doses of BH4 (1.25 mg) initially appear to stimulate detoxification over the first several weeks of use. After this initial detoxification effect, the BH4 appears to have a very positive impact on language for individuals with CBS C699T+ mutations. It seems it is possible to restore BH4 stores through supplementation. Monitoring CBS Status with Biochemical Tests Because of the complexity of addressing CBS mutations, I recommend that people regularly undertake biochemical tests to assess the current status/success of the Ammonia Program. You can do a urine amino acid test (UAA) test at baseline (prior to beginning the Ammonia Program), and follow up in six to eight weeks. At that point, you should be ready to move ahead with methylation supports. However, if you’re uncertain about that, the test results can help to clarify the decision as to when to move forward with the rest of the program. Once you begin to layer in the second priority supports, you should retest periodically to assure that ammonia and taurine remain at desirable levels. You can adjust if they are not. In the following section, you will see what to look for. Indications of CBS Upregulations Any of the following values on test results may be indicators for the CBS upregulation. Changes in these values shown by periodic retesting after you begin to layer in methylation support for second priority mutations will also help you track your forward progress with CBS. UAA Test • Elevated taurine • Elevated ammonia • Decreased citrulline • Decreased methionine • Elevated phenylalanine Autism: Pathways to Recovery 137
OAT/MAP Tests • Elevated hippuric • Decreased fumarate • Elevated phenyl lactate, phenyl acetate, phenylethylamine • Decreased oxaloacetate or decreased oxalates. (Secondary to decreased oxalate you can find elevated hydroxymethylglutarate and elevated hydroxybutyrate. Elevated ammonia requires more urea cycle function, depleting oxaloacetate from the Krebs cycle. Imbalances in oxaloacetate can lead to an increase in the level of hydroxybutyrate.) • Low CO2 • Low creatinine Indications that you have addressed the CBS upregulation UAA Test • Decreased ammonia • Increased creatinine • Decreased taurine • Increased sarcosine • Secondary to increased oxalates: • Increased beta alanine • Increased beta amino isobutyrate • Increased carnosine • Increased anserine In addition to these tests, you can use sulfite and sulfate test strips on a weekly basis to test the conversion of sulfites to sulfates. Mineral Balance for CBS As mentioned earlier, CBS C699T and A360A mutations can deplete molybdenum levels, since molybdenum helps to detoxify sulfur, which tends to accumulate with this mutation. Decreased molybdenum will contribute to imbalance in 138 Autism: Pathways to Recovery
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Autism: Pathways to Recovery NRI Ne
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Copyright © 2004, 2007, 2009 Neuro
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In loving memory of my parents.
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Chapter 2. Nutrigenomics and the Me
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CONCLUSION ........................
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Methylation Cycle Overview ........
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Suggested Protocol to Support Nerve
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exact phrases I might have chosen.
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Chapter 1. Discovering the Pathways
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Chapter 1. Discovering The Pathways
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Chapter 3. Promoting Detoxification
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II. Implementing the New Approach A
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eginning Step Two. If you do the te
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will learn exactly which SNPs are p
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OraPancreas GABA Pycnogenol Grape s
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In summary, rest assured that as yo
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child becomes either overstimulated
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Chapter 7. Step Two, Part Two Ammon
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Chapter 7. Step Two, Part Two also
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Chapter 8. Step Three Remyelinating
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Chapter 8. Step 3 Remyelinating of
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months, he was so obsessed with num
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increase in language would resolve
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contracted encephalitis when she wa
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Alivia recovered in a way that I ha
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Mit’s Story My precious Mit came
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experience of professionals placing
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he is at that moment of his life. I
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ecause it triggers detox/illness fo
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for the first time in nine years I
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Appendix: Flow Chart for Microbes F
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Appendix: Flow Chart for Microbes 2
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Appendix: Flow Chart for Microbes 2
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