3dT4E4Rnm

Strengthening All Parts of the Cycle
In addition to addressing specific mutations, there are major areas of the greater
methylation cycle that nearly all people need to support, which I’ll discuss in this
section of the chapter. Doing so has many benefits: it increases energy levels, and
provides a strong foundation for methylation cycle function by assuring that key
intermediates are available.
Revisiting Gut Support
With respect to the gut, as with all aspects of this protocol, there is no “one size
fits all” approach. Sometimes it is difficult to know where to start with support,
and there is no easy answer. The following is a compilation of suggestions for
overall gut health, taking biochemical testing and Nutrigenomics into account.
As always, work closely with your physician.
After you get your test results, you can also fine tune organ support for the
gut using vitamin C, herbs, Biotene products, xylitol, papaya enzyme, and
other supports that you will find in the gut protocol in the previous chapter.
In addition to supporting the overall methylation cycle, B12 levels also impact
the gut environment. As you gradually layer in B12 support over time, it will also
help to support a healthy gut.
Mitochondrial Support
To support both detoxification process and energy, people of all COMT V158M
and VDR/Taq types should assure that they can get through the adjacent Krebs
cycle (also known as the tricarboxylic or TCA cycle), which is responsible for
generating energy via reactions that take place in the mitochondria. Just as with
the methylation cycle, we need a whole host of intermediates, which can be accessed
via what I call a “mitochondrial support cocktail,” whose ingredients can
be customized based on test results. These results will reveal where deficiencies
lie so that the support can be added.
As you look at this diagram, you can pinpoint where low levels of key intermediates
indicate that you are stuck. For example, if by running a MAP or OAT test,
you discover that you’re stuck at 6:00 or 8:00, you can supplement with ATP,
NADH, and low dose riboflavin.
Typical ingredients in the cocktail are L-carnitine, CoQ10, idebenone, NADH
and a low dose of the Muscle Support RNA. Many of these ingredients contain
methyl groups. That means that some people would do well to slowly layer in
mitochondrial support and/or to rotate the use of these supplements.
160 Autism: Pathways to Recovery