Gene Cloning

34 Gene Cloning
there is an extra chromosome resulting in a total of 47. (c) Triploidy refers to
a condition where there is a complete set of extra chromosomes, in a human
this would mean a total of 69 chromosomes.
Q2.9. Draw a cartoon of a section of a human chromosome containing a
gene. Identify the location of exons, introns and CpG islands. For this gene
to be transcribed and translated in a cell would it need to be in euchromatin
or heterochromatin?
A2.9. Euchromatin contains most of the transcriptionally active genes.
Exons
CpG island
Introns
Further Reading
Genomes 3 (2006) Brown T, Garland Science, London.
Human Molecular Genetics (2003) Strachan T and Read A, Garland Science,
London.
These are two good textbooks that discuss the genome organization and function
Our genome unveiled (2001) Baltimore D, Nature, Volume 409 Pages 814–816.
A commentary on the publication of the human genome sequence with links to more
in-depth articles
The dog has its day (2005) Ellegren H, Nature, Volume 438 Pages 745–746.
A commentary on the publication of the dog genome sequence with links to more indepth
articles
The chimpanzee and us (2005) Li WH and Saunders MA, Nature, Volume 437 Pages
50–51.
A commentary on the publication of the chimpanzee genome sequence with links to
more in-depth articles
The mouse that roared (2002) Boguski MS, Nature, Volume 420 Pages 515–516.
A commentary on the publication of the mouse genome sequence with links to more
in-depth articles
Single nucleotide polymorphisms … to a future of genetic medicine (2001)
Chakravarti A, Nature, Volume 409 Pages 822–823.
A commentary on the publication of a paper reporting the identification and mapping
of SNPs with links to more in-depth articles