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286 C. Christodoulou et al PSYCHIATRIKI 21 (4), 201039. Tedman B, Young C, Williams I. Assessment of depressionin patients with motor neuron disease and other neurologicaldisabling illness. J Neurologic Sci 1997, 152(Suppl1):75–7940. Clarke D, Smith G, Herrman H. A comparative study ofscreening instruments for mental disorders in general hospitalpatients. Int J Psychiatry Med 1993, 23:323–33741. Silverstone P. Poor efficacy of the Hospital Anxiety andDepression Scale in the diagnosis of major depressive inboth medical and psychiatric patients. J Psychosom Res1994, 38:441–45042. Kugaya A, Akechi T, Okuyama H, Uchitomi Y. Screening forpsychological distress in Japanese cancer patients. JapanJ Clin Ongol 1998, 28:333–33843. Trerluin B, Brouwers E, van Marwijk H, Verhaak P, vander Horst H. Detecting depressive and anxiety disorders indistressed patients in primary care, comparative diagnosticaccuracy of the four-dimensional symptom questionnaire(4DSQ) and the Hospital Anxiety and Depression Scale(HADS). BMC Fam Pract 2009, 10:5844. Demyttenaere K, Verhaeghen A, Dantchev N, Grassi L,Montejo A, Perahia D et al. “Caseness” for depressionand anxiety in depressed outpatient population: symptomaticoutcome as function of baseline diagnostic categories.Primary Care Companion. J Clin Psychiatry 2009,11:307–315Corresponding author: Chr. Christodoulou, MD, Ast. Professor ofPsychiatry, 2nd Department of Psychiatry, Medical School, Universityof Athens, "Attikon" General Hospital, 1 Rimini street, GR-124 62Athens, GreeceTel.: 210-58 32 426, Fax: 210-53 26 453e-mail: christo.christodoulou@gmail.com