10:30 am – 12:35 pm SYMPOSIUM – WIRING THE OLFACTORY SYSTEMSChair/Organizer: Jean-Francois CloutierIsland BallroomThe detection of odorant signals from the environment relieson the <strong>for</strong>mation of accurate stereotypical connections betweenolfactory sensory neurons (OSNs) located in the olfactoryepithelium (OE) and second order neurons located in theolfactory bulb (OB). In the mouse, most OSNs expressing asingle olfactory receptor project their axons to twosymmetrically bilateral glomeruli within the OB. How doOSN axons select their target glomeruli in the complexthree dimensional target field that represents an OB? The targetchoice of OSN axons appears to rely on a combination ofmolecular determinants that enhance the growth of axons tothe OB, promote their segregation into broad regions of theOB to <strong>for</strong>m a crude topography and then favor their sortingand coalescence into specific glomeruli. This symposium willexamine recent progress in our understanding of the molecularmechanisms that underlie the <strong>for</strong>mation of an accurateglomerular map.10:35 am #40 Mapping Odorant Receptor Classes in the MouseOlfactory BulbThomas Bozza, Rodrigo Pacifico, Jingji Zhang,and Brian Weiland, Department of Neurobiology andPhysiology, Northwestern University, Evanston, IL,United States11:05 am #41 Axon - matrix interactions regulate olfactory wiringHelen B. Treloar 1 , Arundhati Ray 1 , Lu Anne V. Dinglasan 1 ,Melitta Schachner 3,4 , Charles A. Greer 1,2 . 1 Department ofNeurosurgery, Yale University School of Medicine, New Haven,CT, United States, 2 Department of Neurobiology, YaleUniversity School of Medicine, New Haven, CT, United States,3Zentrum für Molekulare Neurobiologie,Universitätskrankenhaus Hamburg-Eppendorf, Hamburg,Germany, 4 Keck Center <strong>for</strong> Collaborative Neuroscience andDepartment of Cell Biology and Neuroscience, RutgersUniversity, Piscataway, NJ, United States11:35 am #42 Faf1 as a Regulator of Olfactory Axon GuidanceLeonardo Belluscio, Kai Cheng. National Institutes ofHealth / NINDS, Bethesda, MD, United States66 | AChemS <strong>Program</strong> 2010
12:05 pm #43 Reduced Avoidance Response to Predator OdorantsAssociated with Wiring Defects in the Olfactory Systemof Robo-2 Mutant Mice.Jean-François Cloutier 1,2 , Manon Lépine 1,2 , Tyler Cut<strong>for</strong>th 3 ,Jin H. Cho 1,2 . 1 Montreal Neurological Institute, Montreal, QC,Canada, 2 McGill University, Montreal, QC, Canada,3UC Santa Cruz, Santa Cruz, CA, United States12:45 pm – 2:45 pm CLINICAL LUNCHEON (Ticketed Event)NEW CLINICAL TRIAL FUNDING OPPORTUNITIESAT NIDCDChair/Organizer: Claire MurphyGordon Hughes. <strong>Program</strong> Officer, Clinical Trials, NIDCDHorizons#44 The National Institute on Deafness and Other CommunicationDisorders is committed to building and expanding its clinicaltrials program to promote the development of interventions totreat or prevent disorders in hearing, balance, taste, smell, voice,speech and language. Three new clinical trial initiatives andfunding opportunities, issued in July, 2008, can be found athttp://www.nidcd.nih.gov/research/clinicaltrials.Individual application in<strong>for</strong>mation can be found athttp://www.nidcd.nih.gov/funding/foa/. The Phase I/IIPreliminary Clinical Trial specifically targets studies that willprovide preliminary data and optimize the design of theeventual phase III trial. The Phase III Clinical Trial PlanningGrant is designed to permit early peer review of a proposedphase III clinical trial and is used to develop a detailed Manualof Procedures, train clinical sites and prepare case report <strong>for</strong>ms.The Phase III Definitive Clinical Trial should have the potentialto significantly impact on clinical practice or public healthpolicy. NIDCD strongly encourages clinical trial applicationsin chemoreception sciences.S AT U R D AY<strong>Program</strong> in Detail | 67
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