2008 Summer Meeting - Leeds - The Pathological Society of Great ...

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P65Colovesical Fistula - Complicated Diverticular Disease orInvasive Disease?OBoyle 1 , A Peckham-Cooper 1 , KA Laughlan 1 , R Saunders 11 Leeds General InfirmaryA colovesical fistula is an abnormal communication between the bladder andcolon. Initially described by Cripps in 1888, is a well recognized complicationof diverticulitis. However the exclusion of coexisting malignant disease maypresent a diagnostic challenge.A 69 year old gentleman presented with recurrent urinary tract infections,pneumaturia and faecaluria. CT demonstrated thickened sigmoid colon withassociated diverticular disease. A 6cm air containing diverticular abscessextended from the sigmoid colon onto the fundus of the bladder. Air in thebladder confirmed fistulation. Subsequent colonoscopy revealed a largepedunculated polyp, confirmed on histology as a tubular adenoma.Anterior resection, partial cystectomy and reimplantation of left ureter wasperfomed to resect the large sigmoid mass fistulating into the bladder andconfirm histology. A 19cm section of large bowel was excised containing a3.5cm stricture connected anteriorly to inflamed bladder mucosa. Serialsectioning of the stricture showed bowel wall effacement by a circumfrentialsoft, white lesion associated with prominent fibrosis raising the concern ofmalignant disease. Interestingly intra-operative frozen sections confirmedbenign disease.Histological appearance of the resected specimen demonstrated a moderatelydifferentiated, infiltrative adenocarcinoma arising from the colonic mucosainvading through muscularis propria into the pericolic connective tissue with aninflamed fistula tract (pT4). The tumour was accompanied by florid activechronic inflammation with abscess formation and foci of granulomatousinflammation.This case highlights diagnostic challenges associated with the diagnosis andmanagement of colovesical fistulation and importance of exclusion ofmalignant disease in the presence of complicated diverticular disease.P66Pathological Outcomes of Neoadjuvant Chemoradiotherapyfor Locally Advanced Rectal Cancer at Oldchurch and HaroldWood Hospitals. A retrospective study.RRajab 1 ,SRaouf 21 UCLH NHS Trust, 2 Barking Havering & Redbridge NHS TrustAim: To assess the effectiveness of neoadjuvant treatment for locally advancedrectal cancer at our institution, we present the pathological outcomes from acohort of 43 patients that received neoadjuvant chemoradiotherapy prior to totalmesorectal excision.Methods: Patients with locally advanced, biopsy proven rectal carcinomatreated with capecitabine and long course radiotherapy prior to TME, between2001-2006 were identified. Pre-treatment stage and tumour position as assessedby pelvic MRI were collated. Resection specimens were reviewed and tumourtype, yp-stage and status of resection margins were recorded. The pre and posttreatmentT-stages were compared and extent of tumour regression in resectionspecimens assessed (Dworak regression grading).Results: Forty-two patients had adenocarcinoma and one patient hadcloacogenic carcinoma. At presentation 42 patients had T3 disease and 1 patienthad T2 disease with clinically involved regional nodes. Surgical outcomes aresummarized in Table 1. Sixteen patients were down-staged, 6 were sterilised ofdisease and 4 had minimal residual disease, Table 2.Discussion: The frequency of down-staging was less than that achieved in otherstudies (37% v 47% Gavioli et al and 47.6% Yoon et al 2007). Steriliseddisease (14%) and minimal residual disease (9%) were also marginally lower.These differences more likely reflect the smaller size of the study population inthis cohort (a typical workload of a district general hospital in the U.K) thanvariations in the regimens used. Significant down-staging and sterilised diseaseare associated with improved long-term outcomes; however, there remains asmall but significant risk of distant metastasis in patients with minimal residualdisease.Table: 1Surgery Number R0 R1 R2Hartman’s Procedure 1 (2%) 1 0 0Anterior Resection 27 (63%) 25 2 0Abdominoperineal Resection 15 (35%) 14 0 1Table: 2Dworak Tumour RegressionChange in T stage Number of cases (%) 1 2 3 4T3-T4 2 (5%) 1 1 0 0T3-T3 25 (58%) 19 4 2 0T3-T2 8 (19%) 4 3 1 0T3-T1 2 (5%) 1 0 1 0T3-T0 5 (12%) 0 0 0 5T2-T2 0 0 0 0 0T2-T1 0 0 0 0 0T2-T0 1(2%) 0 0 0 1Sterilised disease= Dworak 4, Minimal residual disease= Dworak 348 Summer Meeting (194 th ) 1–4 July 2008 Scientific Programme
P67Tumour Cellularity in Rectal Cancer with and withoutNeoadjuvant Therapy – What is The Relationship?SHasnie 1 ,NWest 1 ,MDattani 1 , P McShane 2 , D Treanor 1 ,J Grabsch 1 , W Mueller 3 ,PQuirke 1 , H Grabsch 1 .1 Pathology and Tumour Biology, Leeds Institute of Molecular Medicine,University of Leeds, UK, 2 Clinical Trials Research Unit, University ofLeeds, UK, 3 Gemeinschaftspraxis Pathologie, Starnberg, GermanyThe RCPath Colorectal Cancer minimum data set requires categorisation of thehistological response to treatment into 'no residual tumour cells', 'minimalresidual tumour' or 'no marked regression'. Terms such as 'minimal' and'marked' seem to be highly subjective. The aim of our study was to establishwhether the tumour composition differs in rectal cancer (RC) with and withoutneoadjuvant therapy and whether the morphometrically measured minimumtumour proportion of the surgery alone group could potentially be a moreobjective and better reproducible marker to identify treatment responders.The proportion of tumour cells (Tu) was quantified by point counting usingvirtual H&E stained slides in 2 independent RC series: A (n = 45, from a singlehospital, treated by surgery alone) and B (n = 27, from multiple centres, treatedby chemoradiation before surgery). Each series was scored by two independentobservers.Establishing tumour components by point counting proved to bereproducible between observers. Tu was significantly different between seriesA (median: 55%, range: 22 to 76%) and B (5%, 0-38%), p
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Page 50 and 51: P71Ciliated foregut cyst of gallbla
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Page 66 and 67: P135Clinical significance of miR-21
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Page 72 and 73: P159Immunohistochemistry Biomarker
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2008 Summer Meeting - Leeds - The Pathological Society of Great ...

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