from first principles PP-I-1

KL-7Transition-Metal-Catalyzed Carbon-Carbon and Carbon-HeteroatomBonds Formation in Organic SynthesisAnanikov V.P.Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences,Leninsky Prospekt 47, Moscow, 119991, Russiaval@ioc.ac.ru; http://www.ioc.ac.ru/val/Carbon-carbon and carbon-heteroatom bonds formation are well-established and outstandingtools utilizing homogeneous catalysis in the areas of organic synthesis, pharmaceutical andmedicinal chemistry, natural product synthesis, material science, and several other fascinatingapplications. Homogeneous catalysis in cross-coupling, Heck, carbonylation reactions, andalso carbon-heteroatom bond formation has shown tremendous recent growth. Rapidmethodology development in the areas of selective construction of C-C and C-Heteroatombonds revealed unique features on the nature of metal catalysis: adaptive interconverion ofdifferent active species taking place during the catalytic transformation.In the present study, the mechanism of transition-metal-catalyzed reactions are discussed inview of evolution of active species in solution and finding the relationship between the natureof catalyst active species to the efficiency and selectivity of the reaction (Scheme 1) [1].Scheme 1. An example of interconversion of Pd catalyst active species in solution.23