Apoptosis and Degenerative Diseases - Bgbunict.it

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The number of people w<strong>it</strong>h neurodegenerativedisorders is rapidly increasing as the averagelifespan gets longer
NEURODEGENERATIVE DISEASESNeurodegenerativediseases are defined bythe progressive loss ofspecific neuronal cellpopulations
Page 1 and 2: Apoptosisand Degenerative diseasesC
Page 3 and 4: Cell death modalities
Page 5 and 6: ApoptosisApoptosis is characterized
Page 7 and 8: The cell begins to shrink following
Page 9: Removal of dead cellsDying cells th
Page 12 and 13: Caspases(cysteine aspartic acidspec
Page 14 and 15: Caspases coordinate demolition of k
Page 16: Apoptotic PathwaysMitochondrial:act
Page 19: Apoptotic PathwaysDeath receptor (e
Page 22 and 23: Following TRADD binding, three path
Page 24 and 25: The activation of NF-κBThe recepto
Page 26 and 27: The ER stress responseApoptosis, as
Page 28 and 29: There is an intensive cross talk be
Page 30: Members of the ‘BH3- only’ subg
Page 36 and 37: A - In Alzheimer’s disease, neuro
Page 38 and 39: Many signals can initiate or ‘tri
Page 40 and 41: Roles for altered synaptic signalli
Page 42 and 43: Oxidative stress refers to a state
Page 44 and 45: Alzheimer’s DiseaseAlzheimer’s
Page 46 and 47: Degenerating neurons show aggregate
Page 48 and 49: Cleavage of APP within the Aβ sequ
Page 50 and 51: NFTs consist of paired helical fila
Page 52 and 53: A series of studies showed that APP
Page 54 and 55: The implication of APP cleavage at
Page 56 and 57: More recently, transgenic mice stud
Page 58: Despite the high protein levels oft
Page 61: Can targeted inhibition of this cla
Page 64 and 65: Parkinson’s DiseaseParkinson's di
Page 66 and 67: Although subject to intensive resea
Page 68 and 69: Defective clearance of modified,tox
Page 70 and 71: Fas-associated factor 1Caspase acti
Page 72 and 73: -FAF1 levels were significantly inc
Page 74 and 75: Huntington’s DiseaseHD is an auto
Page 76 and 77: How does mutant huntingtin promote
Page 79 and 80: Wild-type htt is predominantly cyto
Page 81 and 82: NEURODEGENERATIVE DISEASES ANDTHE M
Page 83 and 84:
MAPK activation occurs through a ca
Page 85 and 86:
MAPKs and Huntington DiseaseMany st
Page 87:
Current therapies are focused on co
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