Apoptosis and Degenerative Diseases - Bgbunict.it
Apoptosis and Degenerative Diseases - Bgbunict.it
Apoptosis and Degenerative Diseases - Bgbunict.it
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Subsequent events in the neurons are glutamate-induced neurotoxic<strong>it</strong>y <strong>and</strong>increased cytosolic Ca 2+ levels, resulting in activation of Ca 2+ -dependent enzymes.These enzymes produce ROS/RNS, which oxidatively modify nucleic acid, lipid,sugar, <strong>and</strong> protein, leading to nuclear damage, m<strong>it</strong>ochondrial damage, proteasomeinhib<strong>it</strong>ion, <strong>and</strong> ER stress.