Apoptosis and Degenerative Diseases - Bgbunict.it

NEURODEGENERATIVE DISEASESA wide variety of them are characterized by the accumulation ofintracellular or extracellular protein aggregates.Once formed, aggregates tend to be resistant to degradation. Cells haveadapted mechanisms to avoid the accumulation of incorrectly foldedproteins. These mechanisms are molecular chaperones that fold proteinscorrectly and the ubiquitin proteasome degradation system that degradesmisfolded or unwanted proteins.In neurodegenerative disorders, these cellular disposal mechanismsbecome ineffective and, as a result, misfolded proteins accumulate andbecome toxic for distinctive sets of neurons.This results in a clinical manifestation of disease