Η μεταγευματική ενεργοποίηση των αιμοπεταλίων ως πιθανός μηχανισμός ανάπτυξης της αθηρωματικής πλάκας12521. Fuster V, Jang IK. Role in platelet-inhibitor agents in coronary arterydisease. In: Textbook of interventional cardiology. 2nd ed. Edited byTopol EJ. Vol1.Philadelphia: Saunders WB, 3-22, 1994.22. Arya M, Lopez JA, Romo GM, et al. Glycoprotein Ib-IX-mediated activationof integrin alpha(IIb)beta(3): effects of receptor clusteringand von Willebrand factor adhesion. J Thromb Haemost 2003;1:1150-1157.23. Kasirer-Friede A, Ware J, Leng L, et al. Lateral clustering of plateletGP Ib-IX complexes leads to up-regulation of the adhesive functionof integrin alpha IIbbeta 3. J Biol Chem 2002; 277:11949-11956.24. Zimmerman GA, McIntyre TM, Mehra M, et al. Endothelial cell-associatedplatelet-activating factor: a novel mechanism for signaling intercellularadhesion. J Cell Biol 1990; 110:529-40.25. McManus LM, Hanahan DJ, Pinckard RN. Human platelet stimulation byacetyl glyceryl ether phosphorylcholine. J Clin Invest 1981; 67:903-6.26. Lindemann S, Tolley ND, Dixon DA, et al. Activated platelets mediateinflammatory signaling by regulated interleukin 1beta synthesis. J CellBiol 2001; 154:485-90.27. Klinger MH. Platelets and inflammation. Anat Embryol (Berl)1997;196:1-11.28. Jennings LK. Mechanisms of platelet activation: Need for new strategiesto protect against platelet-mediated atherothrombosis. ThrombHaemost 2009; 102:248-257.29. Troxler M, Dickinson K, Vanniasinkam SΗ. Platelet function and antiplatelettherapy. British Journal of Surgery 2007; 94:674-682.30. Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis.J Clin Invest 2005; 115(12):3378-84.31. Lusis AJ. Atherosclerosis. Nature 2000; 407:233-41.32. Gawaz M, Stellos K, Langer HF. Platelets modulate atherogenesis andprogression of atherosclerotic plaques via interaction with progenitorand dendritic cells. J Thromb Haemost 2008; 6:235-42.33. Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis.J Clin Invest 2005; 115:3378-3384.34. Huo Y, Schober A, Forlow SB, et al. Circulating activated plateletsexacerbate atherosclerosis in mice deficient in apolipoprotein E. NatMed 2003; 9:61-7.35. Afek A, Kogan E, Maysel-Auslender S, et al. Clopidogrel attenuatesatheroma formation and induces a stable plaque phenotype in apolipoproteinE knockout mice. Microvasc Res 2009; 77:364-9.36. Theilmeier G, Michiels C, Spaepen E, et al. Endothelial von Willebrandfactor recruits platelets to atherosclerosis-prone sites in response tohypercholesterolemia. Blood 2002; 99:4486-93.37. May AE, Kalsch T, Massberg S, et al. Engagement of glycoproteinIIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggersCD40L-dependent matrix degradation by endothelial cells. Circulation2002; 106:2111-7.38. Huo Y, Schober A, Forlow SB, et al. Circulating activated plateletsexacerbate atherosclerosis in mice deficient in apolipoprotein E. NatMed 2003; 9:61-7.39. Levitan EB, Song Y, Ford ES, et al. Is Nondiabetic Hyperglycemia sRisk Factor for Cardiovascular Disease? A Meta-analysis of ProspectiveStudies. Archives of Internal Medicine 2004; 164:2147-2155.40. Brunner EJ, Shipley MJ, Daniel R, et al. Relation Between Blood Glucoseand Coronary Mortality Over 33 Years in the Whitehall Study. DiabetesCare 2006; 29-26-31.41. Glucose tolerance and mortality: comparison of WHO and AmericanDiabetic Association diagnostic criteria. The DECODE study Groupon behalf of the Europe an Diabetes Epidemiology Group. The Lancet-August1999; Vol 354, issue 9179:617-621.42. Hanefeld M, Fischer S, Julius U, et al. Risk factors for myocardial infarctionand death in newly detected NIDDM: the Diabetes InterventionStudy, 11year follow up. Diabetologia 1996; 39:1577-1583.43. Qiao Q, Tuomilehto J, Borch-Johnsen K. Post-challenge hyperglycemiais associated with premature death and macrovascular complications.Diabetologia 2003; 46(suppl.1) M17-21.44. Bonora E, Muggeo M. Postprandial blood glucose as a risk factor forcardiovascular disease in type II diabetes. Diabetologia 2001;44:2107-2114.45. Schuerholz T, Lösche W, Keil O, Friedrich L, Simon T, Marx G. Acuteshort-term hyperglycemia impairs platelet receptor expression evenin healthy adults in vitro. Med Sci Monit 2008; 14(12):BR294-298.46. Vaidyula VR, Rao AK, Mozzoli M, Homko C, Cheung P, Boden G. Effectsof Hyperglycemia and Hyperinsulinemia on Circulating TissueFactor Procoagulant Activity and Platelet CD40 Ligand. Diabetes.2006; 55(1):202-8.47. Valentovic MA, Lubawy WC. Elevated glucose in vivo and in vitro adverselyalters prostaglandin generation in rat aortas and platelets.Prostaglandins Leukot Med 1985; 19(3):271-7.48. Yamagishi SI, Edelstein D, Du XL, Brownlee M. Hyperglycemia potentiatescollagen-induced platelet activation through mitochondrialsuperoxide overproduction. Diabetes 2001; 50(6):1491-4.49. Vaidyula VR, Boden G, Rao AK. Platelet and monocyte activation byhyperglycemia and hyperinsulinemia in healthy subjects. Platelets December2006; 17(8):577-585.50. Sudic D, Razmara M, Forslund M, Ji Q, Hjemdahl P, Li N. High glucoselevels enhance platelet activation: involvement of multiple mechanisms.British Journal of Haematology 2006; 133:315-322.51. Liu D, Maier A, Scholze A, Rauch U, Boltzen U, Zhao Z, Zhu Z, TepelM. High Glucose Enhances Transient Receptor Potential Channel CanonicalType6 Dependent Calcium Influx in Human Platelets via Phosphatidylinositol3-KinaseDependent Pathway. Arterioscler ThrombVasc Biol 2008; 28:746-751.52. Stegenga M, van der Crabben S, Levi M et al. Hyperglycaemia stimulatescoagulation, whereas hyperinsulinaemia impairs fibrinolysis inhealthy individuals. Diabetes 2006; 55:1807-12.53. Haratz D, Stein O, Shwartz R, Berry EM, Stein Y. Preferential metabolismby macrophages of conditioned rabbit hypercholesterolemicremnant lipoproteins. Biochim Biophys Acta 1988;959(2):127-133.54. Iso H, Naito Y, Sato S, et al. Serum triglycerides and risk of coronaryheart disease among Japanese men and women. Am J Epidemiol 2001;153:490-9.55. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfastingtriglycerides and risk of myocardial infarction, ischemic heart disease,and death in men and women. JAMA 2007; 298:299-308.56. Bansal S, Buring J, Rifai N, Mora S, Sacks FM, Rider PM. Fasting comparedwith nonfasting triglycerides and risk of cardiovascular eventsin women. JAMA 2007; 298:309-1657. Jakuji F, Zarnicke K, Bacon S, et al. A high fat meal increases cardiovascularreactivity to physiological stress in health young adults. JNutr 2007; 137:935-939.58. Britt Burton-Freeman. Postprandial metabolic events and fruit-derivedphenolics: a review of the science. British Journal of Nutrition (2010),104:S1-S14.59. Ansar S, Koska J, Reaven PD. Postprandial hyperlipidemia, endothelialdysfunction and cardiovascular risk: focus on incretins. CardiovascDiabetol 2011; 10(1):61.60. Blum S, Aviram M, Ben-Amotz A, Levy Y. Effect of Mediterraneanmeal on post-prandial caretonoids, paraxonase activity and C reactiveproteinlevels. Ann Nutr Metab 2006; 50:20-24.61. Ceriello A, Assaloni R, Roe RD, et al. Effect of arorvastatin and irbesartan,alone and in combination, on post-prandial endothelial dysfaction,oxidative strww and inflammation in type 2 diabetic patients.Circulation 2005; 111:2518-2524.62. Dilley J, Ganesan A, Deepa R, Deepa M, Sharada G, Williams OD,Mohan V. Association of A1C with cardiovascular disease and metabolicsyndrome in Asian Indians with normal glucose tolerance. DiabetesCare 2007; 30(6):1527-32.63. Kris-Etherton PM, Lefevre M, Beecher GR, et al. Bioactive compoundsin nutrition and health-research methodologies for establishing biologicalfunction: the antioxidant and anti-inflammatory effects of flavonoidson atherosclerosis. Annu Rev Nutr 2004; 24:511-538.64. Saniabadi AR, Umemura K, Shimoyama M, Adachi M, Nakano M, NakashimaM. Aggregation of human blood platelets by remnant like lipoproteinparticles of plasma chylomicrons and very low density li-
126 Α. Μικελλίδη, Τ. Νομικόςpoproteins. Thromb Haemost 1997; 77(5):996-1001.65. Knöfler R, Nakano T, Nakajima K, Takada Y, Takada A. Remnant-likelipoproteins stimulate whole blood platelet aggregation in vitro. ThrombRes 1995; 78(2):161-71.66. Mochizuki M, Takada Y, Urano T, Nagai N, Nakano T, Nakajima K,Takada A. The in vitro effects of chylomicron remnant and very lowdensity lipoprotein remnant on platelet aggregation in blood obtainedfrom healthy persons. Thromb Res 1996; 81(5):583-93.67. Saniabadi AR, Umemura K, Suzuki Y, Kondo K, Ikeda Y, Adachi M,Nakashima M. Adenosine 5'-diphosphate as a factor in platelet aggregationinduced by human plasma remnant lipoproteins. Life Sci1998; 63(12):1065-74.68. Tanaka A. Postprandial hyperlipidemia and atherosclerosis. J AtherosclerThromb 2004; 11(6):322-9.69. Fuhrman B, Brook JG, Aviram M. Increased platelet aggregation duringalimentary hyperlipemia in normal and hypertriglyceridemic subjects.Ann Nutr Metab 1986; 30(4):250-60.70. Aviram M, Fuhrman B, Brook JG. Postprandial plasma lipoproteins innormal and hypertriglyceridaemic subjects and their in vitro effect onplatelet activity: differences between saturated and polyunsaturatedfats. Scand J Clin Lab Invest 1986; 46(6):571-9.71. Aviram M, Rosenblat M, Potesman M, Dankner G, Brook JG. Plasmalipoprotein and platelet function after heparin injection: studies innormal fasted and postprandial and in type V hyperlipoproteinemicsubjects. Biochem Med Metab Biol 1986; 35(3):279-92.72. Nimpf J, Malle E, Leopold B, Wurm H, Kostner GM. Postprandial hyperlipemiainhibits platelet aggregation without affecting prostanoid metabolism.Prostaglandins Leukot Essent Fatty Acids 1989; 37(1):7-13.73. Τrovati M, Anfossi G. Insulin, insulin resistance and platelet function:similarities with insulin effects on cultured vascular smooth musclecells. Diabetologia 1998; 41:609-622.74. Μικελλίδη Α, Σταματάκης Γ, Φραγκοπούλου Ε, Αντωνοπούλου Σ, ΔημόπουλοςΚ, Νομικός Τ. O παράγοντας ενεργοποίησης αιμοπεταλίωνεπηρεάζει με χρονοεξαρτώμενο τρόπο τη δράση της ινσουλίνης σεαιμοπετάλια κουνελιού. Ελληνική Επιθεώρηση Αθηροσκλήρωσης,2010; 1(1):94.
Change language