Summary of HIR Equipment (2012-2013) - High Impact Research

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF SCIENCE)No PI's Name Project Title EquipmentEstimated budgetYear 2&3(2012-2013)2012(RM)Approved Budget(After VM Lab)2013(RM)Total(RM)Quantity/UnitOriginCountry ofDetails Justification of purchaseAdditional information(space/utilities eg electric, software etc)Potential users/research groups6Assoc Prof Dr. Koshy PhilipHIR 8 - Mechanism ofbinding of antimicrobialpeptides on targetedbacterial membrane (andits effect on host tissues)1 Visible spectrophotometer 27,000.00 27,000.00 - 27,000.00 1U.S.A.(1) For bacterial culture work - growth curve 1) To develop growth curves of the bacterial cultures used in the study, 1) Self calibration available for the instrumentassays of the antimicrobial compounds 2) Cannot do without the instrument2) Bioassay of antimicrobial compounds 3) Similar instruments are being used intensively by other projects and 2) Model: Genesis Thermo Scientific3) Microbial enzymatic assays researchers 4) Checked that it is available 5) Question of upgrading does not 3) 190 nm - 1100 nm wavelength4) Kinetic growth curve arise as this is an instrument that cannot be upgraded 6) Other researchers 4) Xenon lightassociated with me such as those working on biofuel can also use it 7)Additional bench space can be created for the instrument 8) A market checkwas done before arriving at the price 9) this particular model can fulfil theresearch requirments 10) I do not wish to mention any sole agent 11)Similar equipments available in UM are of older specifications, a reliable onewith updated specifications can provide better quality data for the researchproject as it is critical to publishing tier one papers 12) Maintenance isminimal, calibration can be done by the principal investigator throughregular checks 13) The equipment does not need any software upgrades 14)Hardly any installation or maintenance costs 15) The research project can bedelayed especially with several new post graduate students planned forenrolment in the year 2012 16) Without this equipment, it will be verydifficult to publish in tier one journals 17) It will be used on several times aday - can be used on any microbiology or biotechnology project.27,000.00 27,000.00 -27,000.007Prof Datuk Dr. A.HamidA.HadiHIR 9 - Bioactivecompounds FromMalaysian Plants1 NMR 500MHz with2,500,000.00 2,500,000.00 - 2,500,000.00 1 Japan 500 MHz NMR machine is used to:The 400 MHz NMR machines which belong to the department are heavily This 500 MHz Instrument occupies only small space and themicroprobeused : 1. 90 registered NMR usersdepartment can provided space for this machine. TheIdentified the structure of phytochemicals isolated from plant 2. 35% of users from the Natural products groupelectrical power is needed to run the machine.species. This machine will measure :3. 30 unregistered users per year including the Chemistry Department andfinal year students2 HPLC preparative 600,000.00 - 600,000.00 600,000.00 1 Japan/ This machine is used to separate the enantiomeric compounds This machine is needed for separating the enantiomeric isomers. Without This machine does not require big space. It can be put in theUSA isolated from the plant species. The enantiomeric mixture can this machine, it is difficult to separate the minor component and also the laboratorynot be separated by normal chromatographyical technique. This mixture of enantiomer. Without this machine, it is difficult to publish in tierisvery important intrument especially to identified whether the 1 journal.molecul has R or S configuration and it helps to publish paper intier -1 journal.3 High resolution LC-MS 2,000,000.00 2,000,000.00 - 2,000,000.00 1 Japan/ USA This machine is used for measuring the relatif mass of themolecules. The higest resolution mass is needed for tier-1publications.This instrument will be used to separate every compound present in theextract of the plant species and it also will measure the mass of themolecule at the same time. This will speedup the isolation process and theidentification of the compounds.This machine does not require big space. It can be put in thelaboratory4 Flow cytometer 600,000.00 600,000.00 - 600,000.00 1 USA This machine is used for measuring the cyctotoxicity activity of This machine is needed for the study of mechanism of anticancer activity.the crude and isolated compounds. It is very useful in the study Without mechanism, it is difficult to publish in tier -1 journal. This machineof the cytotoxicity mechanism. With the mechanism, paper can will be used by the natural product group.be published in tier-1 journal.This instrument will be placed in the department ofpharmacy. The department will provide the space for thisinstrument5 Preparative GC 500,000.00 500,000.00 - 500,000.00 1 Japan/ USA Preparative GC is very important instument in the field of This instrument is needed for the isolation of minor volatile compounds. So This instrument can be placed in the department and it needessential oil. The plants also produce essential oil which have far this type of compounds can not be isolated. A lot of new compounds a small space.many commercial appication such as food flavour, fragrant and present in small quantity. This mechine is not available in this university.insect repellent. This instrument is used separate the volatile With this machine, we can isolated the minor compounds and identified thecompounds and at the same time it will give the structure of the structure via spectroscopic technique.compounds. This instrument can help this project to publishpaper in tier-1 journal especially in journal of food and essentialoil.6 GC-MS TOP 1,000,000.00 1,000,000.00 - 1,000,000.00 1 Japan/ USA GC-Mass TOF is used to recognise the mass with special RT This instrument is needed for getting the exact mass of the compound in the This intrument can be placed in the department and it needspeak. Every peak will be identified using mass spectroscopy. It gas phase. We can study the fragmentation pattern of the parent molecule. only small space.helps to publish paper in tier-1 journal.With this data alone we can publish in tier-1 journal.7,200,000.00 6,600,000.00 600,000.007,200,000.008Prof Dr. Kwek Kuan HiangHIR 10 - High EnergyDensity Physics1 Oscilloscopes 130,000.00 - - - 1 USA 1) To capture transient X-ray, current, voltage and laser signals. The 1 GHz analog bandwidth oscilloscopes are necessary because thesignals are all of picosecond risetimes. Two units are required to provideeight channels.2 High vacuum system 31,050.00 - - - 1 UK 2) To establish a vacuum environment of less than 1e-5 torr inthe load chamber for wire ablation experiments.To obtain very low vacuum conditionProject Drop3 Pulse generators 20,000.00 - - - 1 USA 3) To generate low voltage pulses for the synchronization of the To synchronize electronic contral and x-ray systemelectronics that control the laser system, the x-ray imagingsystem and the high voltage generator.181,050.00 - - -- updated on 2nd March 2012 -