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Clinical Trials

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❘❙❚■ Chapter 18 | Significance Tests and Confidence IntervalsTable 3. Point estimate and 95% CI for the difference in mean weight change from baseline between the activedrug and placebo groups in four hypothetical trials of two weight-reduction drugs.Trial Drug No. of Difference in mean Standard Standard 95% CI P-valuepatients weight change from deviation of error of for differenceper group baseline (kg) between difference differencethe active drug andplacebo groups1 A 40 –6 15 3.4 –12.6 0.6 0.0742 A 400 –6 15 1.1 –8.1 –3.9

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