Clinical Trials

■■❚❙❘Chapter 21Analysis ofSurvival DataDuolao Wang, Tim Clayton, and Ameet BakhaiIn clinical research, an endpoint is often the time to theoccurrence of some particular event, such as the death of apatient. These types of data are known as time-to-event dataor survival data. However, the event of interest need not bedeath, but could be some other well-defined event, such asthe first episode of malaria in a vaccine trial or the end of aperiod spent in remission from a disease. The outcome couldalso be a positive event, such as relief from symptoms. In thischapter, we introduce some fundamental methods for theanalysis of such survival data and illustrate their applicationsthrough examples.235