Clinical Trials

Clinical Trials: A Practical Guide ■❚❙❘Table 1. FEV 1measured at pre- and posttreatment and relative change from baseline in 24 patients.Subject Treatment Pretreatment Posttreatment RelativeFEV 1(mL) FEV 1(mL) change (%)1 B 2188 2461 12.52 B 1719 1641 –4.53 B 1875 1641 –12.54 A 1797 2215 23.35 B 1563 1559 –0.36 A 2344 3117 33.07 A 1719 2051 19.38 B 1875 2215 18.19 B 2031 1805 –11.210 A 1719 1969 14.511 A 2016 2264 12.312 A 2188 3117 42.513 B 1875 2051 9.414 B 1797 1969 9.615 B 2500 3035 21.416 A 2266 2953 30.317 B 2422 2625 8.418 A 2031 2379 17.119 A 2500 3035 21.420 B 1875 1723 –8.121 B 2188 2297 5.022 A 1797 2215 23.323 A 1875 2264 20.824 A 1875 2215 18.1Table 2. Summary statistics for pre- and posttreatment FEV 1and relative change by treatment group.Treatment A (active)Treatment B (placebo)Pretreatment Posttreatment Relative Pretreatment Posttreatment RelativeFEV 1(mL) FEV 1(mL) change (%) FEV 1(mL) FEV 1(mL) change (%)Patients 12 12 12 12 12 12Mean 2010.6 2482.8 23.0 1992.3 2085.2 4.0Standard deviation 260.4 437.2 8.5 281.7 456.5 11.3Median 1945.5 2264.0 21.1 1875.0 2010.0 6.7199