Clinical Trials

More documents

Recommendations

Info

❘❙❚■ Chapter 27 | Interaction2. Gail MH, Benichou J, editors. Encyclopedia of Epidemiologic Methods. Chichester:John Wiley & Sons, 2000.3. Gordis L. Epidemiology, 2nd edition. London: WB Saunders Company, 2000.4. GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fattyacids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial.Lancet 1999;354:447–55.5. Chow SC, Liu JP. Design and Analysis of Clinical Trials: Concepts and Methodologies.New York: John Wiley & Sons, 1998.6. Pocock SJ. Clinical Trials: A Practical Approach. New York: John Wiley & Sons, 1983.7. Pocock SJ, Assmann SE, Enos LE, et al. Subgroup analysis, covariate adjustment and baselinecomparisons in clinical trial reporting: current practice and problems. Stat Med 2002;21:2917–30.316
■■❚❙❘Chapter 28RepeatedMeasurementsDuolao Wang and Zoe FoxIn many clinical trials, particularly pharmacokinetic andpharmacodynamic studies, an outcome or marker measurementis recorded at different time points for each subject, generatingrepeated measurement data, which are often correlated.Failure to take account of such correlation in the analysiscould produce biased estimates of true treatment effects.There are various strategies that can be used to analyze suchdata, depending on the questions you wish to answer and thetype of data you will be collecting. In this chapter, we presentan overview of the various strategies for dealing with repeatedmeasurements of a continuous outcome, and explore in moredetail the use of summary measures, which convert mutipledata points into a singular measure (eg, mean or area underthe curve).317
Page 8:
❘❙❚■ ContributorsStephen L
Page 11 and 12:
Clinical Trials: A Practical Guide
Page 13 and 14:
Page 15:
Page 19 and 20:
■■❚❙❘Chapter 1RandomizedC
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31:
Page 34 and 35:
❘❙❚■ Chapter 2 | Uncontroll
Page 36 and 37:
Page 38 and 39:
Page 41 and 42:
■■❚❙❘Chapter 3Protocol De
Page 43 and 44:
Page 45 and 46:
Page 47 and 48:
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
Page 55 and 56:
■■❚❙❘Chapter 4EndpointsAm
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
■■❚❙❘Chapter 5Patient Sel
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
■■❚❙❘Chapter 6Source and
Page 75 and 76:
Page 77 and 78:
Page 79 and 80:
Page 81 and 82:
Page 83 and 84:
■■❚❙❘Chapter 7Randomizati
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91:
Page 94 and 95:
❘❙❚■ Chapter 8 | BlindingBl
Page 96 and 97:
❘❙❚■ Chapter 8 | BlindingTh
Page 98 and 99:
❘❙❚■ Chapter 8 | BlindingAs
Page 100 and 101:
❘❙❚■ Chapter 9 | Sample Siz
Page 102 and 103:
Page 104 and 105:
Page 107:
■■❚❙❘Part IIAlternativeTr
Page 110 and 111:
❘❙❚■ Chapter 10 | Crossover
Page 112 and 113:
Page 114 and 115:
Page 116 and 117:
Page 118 and 119:
100
Page 120 and 121:
❘❙❚■ Chapter 11 | Factorial
Page 122 and 123:
Page 124 and 125:
Page 126 and 127:
Page 128 and 129:
Page 130 and 131:
Page 132 and 133:
❘❙❚■ Chapter 12 | Equivalen
Page 134 and 135:
Page 136 and 137:
Page 138 and 139:
❘❙❚■ Chapter 13 | Bioequiva
Page 140 and 141:
Page 142 and 143:
Page 144 and 145:
Page 146 and 147:
Page 148 and 149:
Page 150 and 151:
❘❙❚■ Chapter 14 | Noninferi
Page 152 and 153:
Page 154 and 155:
Page 156 and 157:
Page 158 and 159:
Page 160 and 161:
❘❙❚■ Chapter 15 | Cluster R
Page 162 and 163:
Page 164 and 165:
Page 166 and 167:
Page 168 and 169:
Page 170 and 171:
152
Page 172 and 173:
❘❙❚■ Chapter 16 | Multicent
Page 174 and 175:
Page 176 and 177:
Page 178 and 179:
Page 180 and 181:
Page 183 and 184:
■■❚❙❘Part IIIBasics ofSta
Page 185 and 186:
■■❚❙❘Chapter 17Types of D
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
■■❚❙❘Chapter 18Significan
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
■■❚❙❘Chapter 19Comparison
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
■■❚❙❘Chapter 20Comparison
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
■■❚❙❘Chapter 21Analysis o
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
■■❚❙❘Part IVSpecial Trial
Page 273 and 274:
■■❚❙❘Chapter 22Intention-
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284: ■■❚❙❘Chapter 23Subgroup A
Page 285 and 286: Clinical Trials: A Practical Guide
Page 291 and 292: ■■❚❙❘Chapter 24Regression
Page 305 and 306: ■■❚❙❘Chapter 25Adjustment
Page 313 and 314: ■■❚❙❘Chapter 26Confoundin
Page 323 and 324: ■■❚❙❘Chapter 27Interactio
Page 333: Clinical Trials: A Practical Guide
Page 347 and 348: ■■❚❙❘Chapter 29Multiplici
Page 357 and 358: ■■❚❙❘Chapter 30Missing Da
Page 371 and 372: ■■❚❙❘Chapter 31Interim Mo
Page 381 and 382: ■■❚❙❘Chapter Part V32Repo
Page 383 and 384: ■■❚❙❘Chapter 32Overview o
Page 385 and 386:
Page 387 and 388:
Page 389 and 390:
Page 391 and 392:
Page 393 and 394:
Page 395 and 396:
■■❚❙❘Chapter 33Trial Prof
Page 397 and 398:
Page 399 and 400:
Page 401 and 402:
Page 403 and 404:
■■❚❙❘Chapter 34Presenting
Page 405 and 406:
Page 407 and 408:
Page 409 and 410:
■■❚❙❘Chapter 35Use of Tab
Page 411 and 412:
Page 413 and 414:
Page 415 and 416:
Page 417 and 418:
Page 419 and 420:
Page 421 and 422:
Page 423 and 424:
Page 425 and 426:
■■❚❙❘Chapter 36Use of Fig
Page 427 and 428:
Page 429 and 430:
Page 431 and 432:
Page 433 and 434:
Page 435 and 436:
Page 437 and 438:
Page 439 and 440:
Page 441 and 442:
Page 443 and 444:
Page 445 and 446:
■■❚❙❘Chapter 37Critical A
Page 447 and 448:
Page 449 and 450:
Page 451 and 452:
Page 453 and 454:
Page 455 and 456:
Page 457 and 458:
■■❚❙❘Chapter 38Meta-Analy
Page 459 and 460:
Page 461 and 462:
Page 463 and 464:
Page 465 and 466:
Page 467 and 468:
Page 469 and 470:
Page 471 and 472:
■■❚❙❘GlossaryGlossary453
Page 473 and 474:
Page 475 and 476:
Page 477 and 478:
Page 479 and 480:
■■❚❙❘AbbreviationsAbbrevi
Page 481 and 482:
Page 483 and 484:
Page 485 and 486:
■■❚❙❘IndexIndex467
Page 487 and 488:
Page 489 and 490:
Page 491 and 492:
Page 493 and 494:
Page 495 and 496:
Page 497 and 498:
show all

Clinical Trials

Create successful ePaper yourself

Delete template?

Save as template?