26.11.2012 Views

Peptide-Based Drug Design

Peptide-Based Drug Design

Peptide-Based Drug Design

SHOW MORE
SHOW LESS

You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

Analysis of Aβ Interactions 85<br />

9. Harper, J.D., Wong, S.S., Lieber, C.M. and Lansbury, P.T. (1997) Observation of<br />

metastable Abeta amyloid protofibrils by atomic force microscopy. Chem. Biol. 4,<br />

119–125.<br />

10. Relini, A., Torrassa, S., Rolandi, R., et al. (2004). Monitoring the process of<br />

HypF fibrillization and liposome permeabilization by protofibrils. J. Mol. Biol. 338,<br />

943–957.<br />

11. Hartley, D.M., Walsh, D.M., Ye, C.P., et al. (1999) Protofibrillar intermediates of<br />

amyloid beta-protein induce acute electrophysiological changes and progressive<br />

neurotoxicity in cortical neurons.J.Neurosci. 19, 8876–8884.<br />

12. Behl, C., Davis, J.B., Lesley, R. and Schubert, D. (1994) Hydrogen peroxide<br />

mediates amyloid beta protein toxicity. Cell 77, 817–827.<br />

13. Ambroggio, E.E., Kim, D.H., Separovic, F., et al. (2005) Surface behavior and<br />

lipid interaction of Alzheimer beta-amyloid peptide 1–42: a membrane-disrupting<br />

peptide. Biophys. J. 88, 2706–2713.<br />

14. Mattson, M.P., Cheng, B., Davis, D., Bryant, K., Lieberburg, I. and Rydel, R.E.<br />

(1992) beta-Amyloid peptides destabilize calcium homeostasis and render human<br />

cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12, 376–389.<br />

15. Curtain, C.C., Ali, F., Volitakis, I., et al. (2001) Alzheimer’s disease amyloid-beta<br />

binds copper and zinc to generate an allosterically ordered membrane-penetrating<br />

structure containing superoxide dismutase-like subunits. J. Biol. Chem. 276,<br />

20466–20473.<br />

16. Dong, J., Atwood, C.S., Anderson, V.E., et al. (2003) Metal binding and oxidation<br />

of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence.<br />

Biochemistry 42, 2768–2773.<br />

17. Pike, C.J., Walencewicz-Wasserman, A.J., Kosmoski, J., Cribbs, D.H., Glabe, C.G.<br />

and Cotman, C.W. (1995) Structure-activity analyses of beta-amyloid peptides:<br />

contributions of the beta 25–35 region to aggregation and neurotoxicity. J.<br />

Neurochem. 64, 253–265.<br />

18. Arispe, N., Rojas, E. and Pollard, H.B. (1993) Alzheimer disease amyloid beta<br />

protein forms calcium channels in bilayer membranes: blockade by tromethamine<br />

and aluminum. Proc. Natl. Acad. Sci. USA 90, 567–571.<br />

19. Guo, Q., Fu, W., Xie, J., et al. (1998) Par-4 is a mediator of neuronal degeneration<br />

associated with the pathogenesis of Alzheimer disease. Nat. Med. 4, 957–962.<br />

20. Wiesner, A. (2004) Detection of tumor markers with ProteinChip technology. Curr.<br />

Pharm. Biotechnol. 5, 45–67.<br />

21. Austen, B.M., Frears, E.R. and Davies, H. (2000) The use of seldi proteinchip arrays<br />

to monitor production of Alzheimer’s betaamyloid in transfected cells. J. Pept. Sci.<br />

6, 459–469.<br />

22. Bradbury, L.E., LeBlanc, J.F. and McCarthy, D.B. (2004) ProteinChip array-based<br />

amyloid beta assays. Methods Mol. Biol. 264, 245–257.<br />

23. Maddalena, A.S., Papassotiropoulos, A., Gonzalez-Agosti, C., et al. (2004)<br />

Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer’s<br />

disease determined by protein biochip technology. Neurodegener. Dis. 1,<br />

231–235.

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!