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BioWorld® - Medical Device Daily

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BioWorld Industrial Biotechnology StatReport: Immediate and Comprehensive Industry Information<br />

Genzyme Virotech GmbH--Germany<br />

Genzyme Hellas LLC--Greece<br />

Genzyme Europe BV Kepviselet--Hungary<br />

Genzyme Ireland Ltd.<br />

Genzyme Italy<br />

Genzyme Polska Sp. z o.o.--Poland<br />

Genzyme Portugal<br />

Genzyme Barcelona<br />

Genzyme Madrid<br />

Genzyme GmbH--Switzerland<br />

Genzyme Sygena--Switzerland<br />

Genzyme Cambridge--U.K.<br />

Genzyme Ltd.--U.K.<br />

Genzyme Oxford--U.K.<br />

Verigen Australia Pty. Ltd.--Australia<br />

Genzyme China<br />

Genzyme Asia Ltd.<br />

Genzyme Tokyo<br />

Genzyme Korea<br />

Genzyme Singapore Pte. Ltd.<br />

Genzyme GmbH Russia<br />

Genzyme Taiwan<br />

INVESTMENTS: Genzyme Clinical Partners LP--reacquired the assets for 1.4M shares of<br />

Genzyme common stock (2/90)<br />

RenaGel LLC--joint venture with GelTex Pharmaceuticals, Inc. to handle<br />

development and commercialization of GelTex's RenaGel non-absorbed<br />

phosphate binder<br />

Abiomed Inc.--14%<br />

50/50 joint venture with Genzyme Transgenics Corp.--$33M (7/97)<br />

Joint venture with BioMarin Pharmaceutical Inc.<br />

Joint venture with Pharming Group NV (7/98)<br />

AGREEMENTS: Name Products Content of Agreement Date<br />

Acadia<br />

Acadia's cell-based collaborative 10/97<br />

Pharmaceuticals screening technology screening<br />

Inc.<br />

and Genzyme's library<br />

of more than 1M<br />

compounds<br />

agreement<br />

Alcon Labs ophthalmic products supply agreement 12/86<br />

(Nestle)<br />

using hyaluronic acid<br />

such as Surgicoat<br />

Angiotech<br />

identification,<br />

strategic<br />

5/06<br />

Pharmaceuticals development and collaboration<br />

Inc.<br />

commercialization of<br />

therapies for cancer<br />

patients undergoing<br />

surgical removal of<br />

tumors<br />

agreement<br />

Aronex<br />

Atragen development and 3/97<br />

Pharmaceuticals<br />

marketing<br />

Inc.<br />

agreement (9/93),<br />

amended--<br />

Genzyme has<br />

option to<br />

commercialize<br />

ArQule Inc. drug candidates for<br />

identifying cancer,<br />

infectious diseases and<br />

autoimmune/inflammato<br />

ry diseases<br />

development<br />

agreement--ArQule<br />

to provide<br />

Genzyme with<br />

access to Mapping<br />

Array program for<br />

identifying new lead<br />

compounds against<br />

Genzyme's targets<br />

Copyright ©2006 AHC Media ® 176<br />

4/97

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