Review of the Air Quality Criteria Document for Particulate Matter

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8-87 20 delete "however,".8-88 Section 8.7 SUMMARY ignored the discussion in Section8.5.3 on "Potential Cellular and Molecular Mechanisms"(pp. 8-58 through 8-68). Was it because it had no apparentrelevance to the issues at hand?... or because the resultscited were too various and confusing to show how furtherresearch on biological mechanisms can be structured toadvance the understandings needed to guide theidentification of the physical and chemical properties ofambient PM that lead to adverse health effects. Thissummary section is incomplete without a reasoned summaryof what previous research on biological mechanisms of PMhealth effects has determined, and how strategic planningfor further research efforts can best be structured to resolvethe unknowns in this important area.CHAPTER 9 - INTERACTIVE SYNTHESIS - General CommentIn general, this chapter is well organized and provides a clear summary statement and synthesisof the PM literature described in the preceding chapters. It will, of course, need some finetuning, updating, and more definitive conclusions following receipt of CASAC and publiccomments. It is well on its way to serving its intended purpose and represents a welcomeevolution from earlier PM criteria documents.Specific CommentsPage(s) Line(s) Comments9-3 3 insert "for regulatory purposes" after "pollutants".9-4 4 change "enter" to "penetrate".9-4 5 change "excluded" to "retained".9-4 11 insert "or trimodal" after "bimodal" and "minimum between1.0 and 3.0 :m" to "minima at about 0.06 and 2.0 :m". Thefigure referred to (Figure 9-1) is clearly trimodal, eventhough it represents the special case of near major roadways.9-4 13 change "the" to "that".9-7 10 insert "and PM10 includes only those coarse mode particlesthat can penetrate into the human thorax" after "equivalent".9-7 28 insert ", which are predominantly in the fine mode" after"compounds", and insert ", which is predominantly in thecoarse mode" after "material".9-9 15 insert "relatively" after "only".9-26 1 The authors should know better than to give credence to thenotion of "some exposure analysts feel that ambientconcentrations represent a surrogate for total personalexposure". This is a place where what we know should takeprecedence over ill-considered conjecture!A - 45
9-27 17 insert "source and/or" after "each".9-27 27 change "several" to "many (~16)".9-28 15 change "lower" to "smaller".9-28 22 insert "directly proportional to the number of charges"before "inversely".9-28 23 change "likely" to "generally".9-30 5 change "and through segmental bronchi" to ", bronchi andbronchioles". There are "hot spots" on deposition onbifurcations at all branching levels, as I noted in my reviewof the Dosimetry chapter.9-30 8-10 This statement is flat-out wrong, and needs to bereconsidered. Deposition peaks in the segmental bronchi.9-32 29 "mucociliary" is misspelled.9-33 24 change "(< 24 h)" to "(< 10 days)". The clearance viaalveolar macrophages is minimal during the first 24 hours.9-33 26 insert "moderately" before "soluble". Highly solublematerials do not retain their particulate form long enough tobe translocated.9-35 11 change "particles" to "deposits".9-39 15 for consistency, insert "(SOx)" after "sulfur oxides", "(NOx)"after "nitrogen oxides", and "(O3)" after "ozone".9-66 26 The "McConnell et al" reference is to one of the papers fromthe CARB sponsored children's health study at USC. Thereference here should be to a paper by McDonnell et al onthe AHSMOG data.9-69 Figure 9-9 There is no translation given for the "HF" and "1 HD"caption designations in the figure. They refer to congestive heartfailure and ischemic heart disease respectively. This also appliesto Figure 6-6.9-74 Figure 9-10 The hospital admissions data for Detroit reported byLippmann et al. (2000) should be included in this summarypresentation data. This also applies to Figure 6-7.9-79 and Section 9.6.2.3.3 This section is incomplete without discussion of a recentseries of important papers from the Children's HealthStudy in Southern California. In particular, discussionneeds to be added for the following:9-80 A. Papers that were cited in Chapter 6: 1) McConnell et al.,EHP, 1999; 2) Peters, J.M. et al., Am. J. Resp. Crit. CareMed., 1999b and c; 3) Gauderman et al., Am. J. Resp. Crit. CareA - 46
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Review of the Air Quality Criteria Document for Particulate Matter

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