2,4,6-trinitrotoluene (TNT) - OEHHA

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10 Other Relevant Data • Pharmacokinetics & Metabolism • Genotoxicity • Structure Activity Comparisons with Proposition 65 Carcinogens Office of Environmental Health Hazard Assessment
11 Pharmacokinetics & Metabolism of <strong>TNT</strong> • Absorption: GI tract, skin & lungs • Distribution: Primarily to the liver, kidneys, lungs & fat • Elimination: Primarily via urinary excretion • Metabolism: -Nitroreduction of aromatic nitro groups to hydroxylamino derivatives -Oxidation of methyl group to benzyl alcohol & benzoic acid derivatives Office of Environmental Health Hazard Assessment
Page 1 and 2: 1 2,4,6-Trinitrotoluene (TNT) CAS N
Page 3 and 4: 3 Carcinogenicity Studies of TNT
Page 5 and 6: 5 TNT-Exposed Munitions Workers and
Page 7 and 8: 7 Tumors in Female F344 Rats Fed TN
Page 9: 9 Summary of Carcinogenicity Studie
Page 13 and 14: 13 TNT Genotoxicity : Bacterial Sys
Page 15 and 16: 15 TNT Genotoxicity: Mammalian In V
Page 17 and 18: 17 Genotoxicity of TNT Metabolites
Page 19 and 20: Structure-Activity Comparisons with
Page 21 and 22: 21 Authoritative Body Reviews • U

2,4,6-trinitrotoluene (TNT) - OEHHA

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