2,4,6-trinitrotoluene (TNT) - OEHHA

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16 TNT Genotoxicity in Humans • No difference between TNT-exposed and control workers in frequency of chromosomal aberrations (CA) in peripheral blood lymphocytes � Among TNT-exposed workers —Increased CA in NAT1 rapid vs. slow acetylator genotype � Among TNT-exposed workers with NAT1 rapid acetylator genotypes —Increased CA associated with GSTM1 null or GSTT1 null genotypes Office of Environmental Health Hazard Assessment
17 Genotoxicity of TNT Metabolites 2-ADNT 4-ADNT 2,4-DANT 2,6-DANT Salmonella mutation assays (TA 98, TA100) + + + + CHO-HPRT mutation assay V79-HGPRT mutation assay 4-NHOH-DNT - + (S9) - + (weak) - + (weak) - - - Positive: in vitro oxidative DNA damage (8-oxodG); cleaves DNA at sites with consecutive guanines Office of Environmental Health Hazard Assessment
Page 1 and 2: 1 2,4,6-Trinitrotoluene (TNT) CAS N
Page 3 and 4: 3 Carcinogenicity Studies of TNT
Page 5 and 6: 5 TNT-Exposed Munitions Workers and
Page 7 and 8: 7 Tumors in Female F344 Rats Fed TN
Page 9 and 10: 9 Summary of Carcinogenicity Studie
Page 11 and 12: 11 Pharmacokinetics & Metabolism of
Page 13 and 14: 13 TNT Genotoxicity : Bacterial Sys
Page 15: 15 TNT Genotoxicity: Mammalian In V
Page 19 and 20: Structure-Activity Comparisons with
Page 21 and 22: 21 Authoritative Body Reviews • U

2,4,6-trinitrotoluene (TNT) - OEHHA

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