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2,4,6-trinitrotoluene (TNT) - OEHHA

2,4,6-trinitrotoluene (TNT) - OEHHA

2,4,6-trinitrotoluene (TNT) - OEHHA

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14<br />

<strong>TNT</strong> Genotoxicity: Mammalian In Vitro Systems<br />

• Rat<br />

—Negative: in vitro liver UDS assay<br />

• Mouse<br />

—Positive: P388 lymphoma TK locus mutation<br />

assay (-S9)<br />

• Hamster<br />

—Positive: CHO-HPRT mutation assay (+S9)<br />

—Negative: V79-HGPRT mutation assay<br />

Office of Environmental Health Hazard Assessment

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