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2,4,6-trinitrotoluene (TNT) - OEHHA

2,4,6-trinitrotoluene (TNT) - OEHHA

2,4,6-trinitrotoluene (TNT) - OEHHA

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22<br />

<strong>TNT</strong>: Summary of Evidence<br />

• Humans<br />

—Not adequately studied<br />

—Suggestion from case reports and controlled<br />

studies of liver cancer & leukemia<br />

• Animals<br />

—Rare urinary bladder tumors in female rats<br />

—Leukemias/malignant lymphomas of the spleen<br />

in female mice<br />

• Other relevant evidence<br />

—Genotoxicity of <strong>TNT</strong> & its metabolites<br />

—Structural similarity to the carcinogens<br />

2-nitrotoluene, and 2,4- and 2,6-dinitrotoluene<br />

Office of Environmental Health Hazard Assessment

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