2,4,6-trinitrotoluene (TNT) - OEHHA
2,4,6-trinitrotoluene (TNT) - OEHHA
2,4,6-trinitrotoluene (TNT) - OEHHA
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13<br />
<strong>TNT</strong> Genotoxicity : Bacterial Systems<br />
Salmonella typhimurium Reverse Mutation Assays<br />
•Positive in strains TA98, TA1537, TA1538<br />
& TA100<br />
-Frameshift & basepair substitution<br />
-Presence or absence of metabolic activation<br />
-Requires nitro reductase, o-acetyltransferase<br />
Escherichia coli SOS Chromotest<br />
•Positive (human placenta microsomal system)<br />
•Negative (rat liver S9)<br />
Office of Environmental Health Hazard Assessment
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