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2,4,6-trinitrotoluene (TNT) - OEHHA

2,4,6-trinitrotoluene (TNT) - OEHHA

2,4,6-trinitrotoluene (TNT) - OEHHA

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18<br />

Urine Mutagenicity<br />

• Rats treated with <strong>TNT</strong><br />

—Positive in Salmonella<br />

• Humans exposed to <strong>TNT</strong><br />

—Increased mutagenicity in Salmonella of<br />

urine from exposed as compared with<br />

unexposed controls<br />

—Higher in NAT1 rapid vs. slow acetylators<br />

Office of Environmental Health Hazard Assessment

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