2,4,6-trinitrotoluene (TNT) - OEHHA

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12 Metabolism The major metabolic pathways of <strong>TNT</strong> (adapted from Bolt et al., 2006). Office of Environmental Health Hazard Assessment
13 <strong>TNT</strong> Genotoxicity : Bacterial Systems Salmonella typhimurium Reverse Mutation Assays •Positive in strains TA98, TA1537, TA1538 & TA100 -Frameshift & basepair substitution -Presence or absence of metabolic activation -Requires nitro reductase, o-acetyltransferase Escherichia coli SOS Chromotest •Positive (human placenta microsomal system) •Negative (rat liver S9) Office of Environmental Health Hazard Assessment
Page 1 and 2: 1 2,4,6-Trinitrotoluene (TNT) CAS N
Page 3 and 4: 3 Carcinogenicity Studies of TNT
Page 5 and 6: 5 TNT-Exposed Munitions Workers and
Page 7 and 8: 7 Tumors in Female F344 Rats Fed TN
Page 9 and 10: 9 Summary of Carcinogenicity Studie
Page 11: 11 Pharmacokinetics & Metabolism of
Page 15 and 16: 15 TNT Genotoxicity: Mammalian In V
Page 17 and 18: 17 Genotoxicity of TNT Metabolites
Page 19 and 20: Structure-Activity Comparisons with
Page 21 and 22: 21 Authoritative Body Reviews • U

2,4,6-trinitrotoluene (TNT) - OEHHA

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