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2,4,6-trinitrotoluene (TNT) - OEHHA

2,4,6-trinitrotoluene (TNT) - OEHHA

2,4,6-trinitrotoluene (TNT) - OEHHA

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15<br />

<strong>TNT</strong> Genotoxicity: Mammalian In Vivo Systems<br />

• Rat<br />

—Negative: liver UDS assay<br />

—Negative: bone marrow cytogenetic damage<br />

—Positive: oxidative DNA damage (8-oxodG) in<br />

sperm cells<br />

• Mouse<br />

—Negative: bone marrow micronucleus assay<br />

Office of Environmental Health Hazard Assessment

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