2,4,6-trinitrotoluene (TNT) - OEHHA

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20 Potential Mechanisms of Carcinogenicity • Genotoxicity - Mutation - Induction of oxidative DNA damage Office of Environmental Health Hazard Assessment
21 Authoritative Body Reviews • US EPA (1993) —Reviewed animal studies by Furedi et al. (1984a,b) —Did not include any human studies —Did not include several studies on metabolism, genotoxicity, biomarkers of exposure —Group C: “possible human carcinogen” • IARC (1996) —Did not include the epidemiology studies of Kilian et al. (2001), Yan et al. (2002) —Did not include animal cancer studies —Did not include several recent studies on metabolism, genotoxicity, biomarkers of exposure —Group 3: “not classifiable as to carcinogenicity in humans” Office of Environmental Health Hazard Assessment
Page 1 and 2: 1 2,4,6-Trinitrotoluene (TNT) CAS N
Page 3 and 4: 3 Carcinogenicity Studies of TNT
Page 5 and 6: 5 TNT-Exposed Munitions Workers and
Page 7 and 8: 7 Tumors in Female F344 Rats Fed TN
Page 9 and 10: 9 Summary of Carcinogenicity Studie
Page 11 and 12: 11 Pharmacokinetics & Metabolism of
Page 13 and 14: 13 TNT Genotoxicity : Bacterial Sys
Page 15 and 16: 15 TNT Genotoxicity: Mammalian In V
Page 17 and 18: 17 Genotoxicity of TNT Metabolites
Page 19: Structure-Activity Comparisons with

2,4,6-trinitrotoluene (TNT) - OEHHA

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