Series VI: Medical Sciences – SUPPLEMENT ... - Krongres

A. BALESCU et al: The Aspirin- The First Drug Obtained by Synthesis - Frequently Used Currently 147
• Antipyretic;
• Anti-inflammatory – the treatment of
acute articular rheumatism and other
acute inflammatory diseases; after
1950, by discovering other drugs
with analgesic, antipyretic and antiinflammatory
actions the aspirin had
major competitors;
• As an antithrombotic agent – in the
prophylaxis of acute myocardial
infarction, acute angina, transitory
acute angina and ischemic cerebrovascular
stroke; in 1971 the pharmacist
John Robert Vane proves the effects of
the aspirin on prostaglandins [2] and
the antithrombotic effect of the aspirin,
fact that determines the use in the
prophylaxis of cardiovascular diseases,
this being the moment of the
commercial revival of the aspirin; at
the European Society of Cardiology
Congress, in Barcelona, 2009, were
described the results of studies done in
Scotland on 29000 persons with ages
between 50 and 75 followed for 8
years; the conclusions suggest that the
aspirin should not be prescribed to the
general population because the healthy
persons that take aspirin do not reduce
their cardiac risk but increase their
hemorrhagic risk [4].
• As antithrombotic agent – in the
treatment of cardiovascular cerebrovascular
diseases; it is ascertained
the favorable effect in the secondary
prevention of those diseases; but in
the case of the primary prevention
the benefit from administering
aspirin are annulled by the high risk
of cerebral hemorrhage [3].
Recently it was confirmed that the
aspirin has n important role also in:
• Pancreatic cancer prevention – the
results of some epidemiologic
studies suggested that aspirin can
reduce the risk of pancreatic cancer,
but this conclusion is not fully
endorsed; research conducted on
987,590 persons with a evolution
followed for 18 years (1982-2000)
demonstrated that the sue of aspirin
with the purpose to reduce the
pancreatic cancer incidence or the
mortality caused by it does not have
a significant effect [1].
• The prevention of hepatic diseases
caused by alcohol and medication
overdose – a study done by Yale
University shows that daily use of
aspirin is preventing hepatic
diseases; for prevention a daily dose
of aspirin is recommended and if the
lesions are already present it is
recommended the administering of
immune stimulant substances;
• Decrease of relapse risk for colon
and rectal cancers [3]; the
mechanism of action of the aspirin
on tumor development is not well
known, it is considered that some
aspirin doses act at endothelial level,
controlling the development of the
blood vessels and implicit the
development of the tumor; these test
have been done only at a laboratory
level and are necessary studies to
confirm this hypothesis;
• The prevention of some types of
cataract – research done by the Yale
University shows that the salicylic
acid is capable to prevent or delay
the onset of the cataract, acting on an
enzyme involved in the sorbitol
creation in the crystalline;
• Prevention of severe migraines;
• Prevention of obesity;
• Effects on arterial tension – aspirin
administered in the morning
increases the arterial tension and in
the evening decreases the arterial
tension;
• The association of aspirin with
caffeine and ephedrine can have a
positive influence on the