7817 Annual Report 2009.qxd - Shire

Shire plc Annual Report and Accounts 200963Independent auditors’ report to the members of Shire plcWe have audited the accompanying consolidated balance sheets of Shire plc and subsidiaries as of December 31, 2009 and 2008, and the relatedconsolidated statements of operations, shareholders’ equity, comprehensive income/(loss), cash flows for each of the three years in the period endedDecember 31, 2009 and the related Notes 1 to 36 (together, the ‘Financial Statements’). These Financial Statements have been prepared in conformitywith accounting principles generally accepted in the United States of America. We have also audited the information in the Directors’ remunerationreport that is described as having been audited.We have reported separately on the parent company financial statements of Shire plc for the year ended December 31, 2009.This report is made solely to the Company’s members, as a body. Our audit work has been undertaken so that we might state to the Company’smembers those matters we are required to state to them in an auditors’ report and for no other purpose. To the fullest extent permitted by law,we do not accept or assume responsibility to anyone other than the Company and the Company’s members as a body, for our audit work, for thisreport, or for the opinions we have formed.Respective responsibilities of Directors and auditorsThe Directors’ responsibilities for preparing the Annual Report, the Directors’ remuneration report and the Financial Statements are set out in theStatement of Directors’ responsibilities. Our responsibility is to audit the Financial Statements and the part of the Directors’ remuneration reportto be audited in accordance with relevant legal and regulatory requirements and International Standards on Auditing (United Kingdom and Ireland).Those standards require us to comply with the United Kingdom Auditing Practices Board’s (APB’s) Ethical Standards for Auditors.Scope of the audit of the Financial StatementsAn audit involves obtaining evidence about the amounts and disclosures in the financial statements sufficient to give reasonable assurance that thefinancial statements are free from material misstatement, whether caused by fraud or error. This includes an assessment of: whether the accountingpolicies are appropriate to the group’s circumstances and have been consistently applied and adequately disclosed; the reasonableness of significantaccounting estimates made by the directors; and the overall presentation of the financial statements.Opinion on the Financial StatementsIn our opinion the Financial Statements:— present fairly, in all material respects, the financial position of Shire plc and subsidiaries as of December 31, 2009 and 2008, and the results of itsoperations and cash flows for each of the three years in the period ended December 31, 2009, in conformity with accounting principles generallyaccepted in the United States of America; and— have been prepared in accordance with the requirements of the United Kingdom Companies Act 2006 that would be specified by United Kingdomlaw were the Company incorporated in the United Kingdom.Opinion on other matters that would be prescribed by the United Kingdom Companies Act 2006 were the Company incorporated in theUnited KingdomIn our opinion:— the information given in the Directors’ report for the financial year for which the financial statements are prepared is consistent with the FinancialStatements; and— the part of the Directors’ remuneration report to be audited has been properly prepared in accordance with the United Kingdom Companies Act2006.Matters on which we are required to report by the Listing RulesWe have nothing to report in respect of our duty under the Listing Rules to review:— the Directors’ statement contained within the Financial Statements in relation to going concern; and— the part of the Corporate governance statement relating to the Company’s compliance with the nine provisions of the June 2008 Combined Codespecified for our review.Deloitte LLPChartered Accountants and Registered AuditorsLondon, United KingdomFebruary 26, 2010