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74 Basic Poster SessionsIBP 023Characterization of the Age Related Macular Degeneration in Donor EyesS Sudha Priya, 1 T Amala Raja Sundari, 1 Anand Rajendran, 2 VR Muthukkaruppan 11Department of Immunology and Cell Biology, Aravind Medical Research Foundation,Dr G Venkataswamy Eye Research Institute, Madurai, 2 Retina and Vitreous Service, Aravind EyeHospital, Madurai, India.Purpose: Age-related macular degeneration (AMD) is a complex ocular disorder, characterizedby progressive and irreversible loss of central vision due to degeneration of macula. In order tounderstand the aetiology and pathogenesis of AMD in humans, we make use of donor eyes andthe present study is to identify/grade AMD and to confirm by histopathology.Methods: Donor Eyes (15-93 years) were provided by Rotary Aravind International Eye bank.The macular region was digitally imaged through stereo-dissection microscope with fiber opticlighting. A grid was superimposed on the images and graded as per the Minnesota Gradingsystem (MGS) on the basis of drusen size, area of depigmentation and area of atrophy byusing illustrator software program. The macular region was processed for histopathologicalanalysis and AMD phenotype was confirmed by following both Alabama age-related maculardegeneration grading system (AGS) and Sark’s classification. Macula of young (60 years) without AMD were also examined as control.Results: Among the 156 donor eyes examined, we found that two belonged to the early AMD(grade 2/3), with soft drusen of size ≥125µm, hypopigmentation and missing of photoreceptorouter segment. The third donor belonged to intermediate type of AMD, wherein retinal pigmentepithelial cells located outside the fovea were reduced in number and size. Donor eyes withhard drusen (