organisation - the Instituto Gulbenkian de CiÃªncia

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GENE EXPRESSION UNIT Jörg Becker Head PhD in Biology, University of Bielefeld, Germany, 2001 Research Fellow - Plant Genomics Group Head of Facility since 2008 The Gene Expression Unit provides DNA microarray services, ranging from experimental design over complete sample processing to expert advice on data analysis. We have been an Affymetrix Core Lab with reference status for Gene- Chip technology in Portugal since 2002. Running a total of 339 microarrays we have contributed to 32 in-house, national and international projects in 2011 alone. FACILITY STAFF Júlia Lobato (Technician) João Sobral (Technician, started in October) SERVICES INCLUDE: • Gene Expression Profiling (3’ IVT, Gene and Exon arrays); • Genotyping, Cytogenetics (500K array set and SNP 6.0 array); • Custom array projects; • RNA and DNA quality analyses (Bioanalzyer); • Data analysis training (dChip and Chipster). MAJOR PROJECTS AND ACCOMPLISHMENTS • Training SNP6 Cytogenetics (5 SNP6 Genotyping arrays for Gene Expression Unit); • Sperm Transcriptome (4 Drosophila arrays for Plant Genomics lab); • NKTreg (5 Mouse arrays (Cellular Immunology lab for IGC associated group at IMM); • Myc Factor (1 Medicago arrays for Institute for Plant Genetics, Leibniz University Hanover, Germany); • AGP mutant pollen (6 Arabidopsis arrays for Department of Botany, Faculdade de Ciências da Universidade do Porto, Portugal); • Cholesterol and Metastasis (6 Human arrays for Centro de Investigação de Patobiologia Molecular, Lisbon); • Zinc Finger (3 Human arrays for Faculty of Pharmacy, University of Lisbon); • Chein Myf5 (2 Mouse Tiling arrays for Patterning and Morphogenesis lab); • Leukemia (16 human arrays for IGC associated group at IMM); • Retinoic Acid in Enteric Lymphoid Organogenesis (8 Mouse arrays for IGC associated group at IMM); • Drg11 (20 Mouse arrays for Department of Experimental Biology, Faculdade de Medicina da Universidade do Porto); • Xspecies (4 Burkholderia arrays for Biological Sciences Research Group, Instituto Superior Técnico, Lisbon); • SNP6 Genotyping (3 SNP6 Genotyping arrays for Department of Genetics, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon); • Small RNAs (15 Arabidopsis arrays for Oeiras Summer Schools in Evolutionary Biology, IGC); • Ontogeny vs. Phylogeny (15 Mouse arrays for Oeiras Summer Schools in Evolutionary Biology, IGC); • Regeneration in denervated fins (16 zebrafish arrays for IGC associated group at IMM); • Zymosan treatment (12 Anopheles/Plasmodium arrays for UEI Parasitologia Médica, Instituto de Higiene e Medicina Tropical, Lisbon); • Stem cell differentiation (2 Human arrays for Department of Medical Genetics, Faculdade de Medicina da Universidade do Porto); • Dis delta phenotype (6 Yeast arrays for Control of Gene Expression Lab, ITQB); • BolA overexpression (6 E.coli arrays for Control of Gene Expression Lab, ITQB); • NeoSuc clinical trial (34 human arrays for Computational Genomics Group, IGC); • Cytogenetics (2 Cyto 2.7M arrays for Department of Genetics, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon); • Variants (12 Burkholderia arrays for Biological Sciences Research Group, Instituto Superior Tecnico, Lisbon); • LMD Myc (5 Medicago arrays for Institute for Plant Genetics, Leibniz University Hanover, Germany); B Fluidics station for staining and washing up to 4 GeneChips in parallel. Pseudo-coloured image of a GeneChip array after scanning, showing different signal intensities depending on the expression level of the correspondent transcripts. IGC ANNUAL REPORT ‘11 FACILITIES AND SERVICES 92
• Low noise (6 Rat arrays for Instituto Superior Ciências da Saúde Egas Moniz, Lisbon); • Forest Biotech (12 Poplar arrays for Forst Biotech group, IBET); • Malaria lipids (3 Mouse arrays for IGC associated group at IMM); • SMc3169 (6 Medicago arrays for Biological Sciences Research Group, Instituto Superior Tecnico, Lisbon); • Breast Cancer (4 Human arrays for Centro de Investigação de Patobiologia Molecular, Lisbon); • FuncGrape (32 Vitis vinifera arrays for Genomics and Plant Breeding, Instituto Superior de Agronomia, Lisbon); • GWAS Behcet (16 SNP6 Genotyping arrays for IGC associated group at IMM); • HIV (3 Human arrays for Infections and Immunity group, IGC). EQUIPMENT AND INFRASTRUCTURE • Scanner 3000 7G with Autoloader; • Fluidics Station 450; • Hybridization Oven 640; • Bioanalyzer 2100. Funding Fundação para a Ciência e a Tecnologia, Portugal IGC ANNUAL REPORT ‘11 FACILITIES AND SERVICES 93
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The Instituto Gulbenkian de Ciênci
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ORGANISATION CALOUSTE GULBENKIAN FO
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established a unique and diverse hu
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After all these years of a half-dis
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IGC ANNUAL REPORT ‘11 THE DIRECTO
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30 Nationalities working at the IGC
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2004 - 2011 NEW RESEARCH GRANTS BRE
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PROTEIN-NUCLEIC ACIDS INTERACTIONS
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MEIOSIS AND DEVELOPMENT Vítor Barb
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EPIGENETICS AND SOMA Vasco M. Barre
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VARIATION: DEVELOPMENT AND SELECTIO
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as a manuscript submitted in 2011 (
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We have found a new precursor struc
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We have previously developed a sper
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POPULATION AND CONSERVATION GENETIC
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NEUROBIOLOGY OF ACTION Rui M. Costa
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During this year we demonstrated th
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CELL BIOPHYSICS AND DEVELOPMENT Jos
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GENOME-WIDE ANALYSIS OF TELOMERE PR
Page 41 and 42: Improved ICT techniques and methodo
Page 43 and 44: ACTIN DYNAMICS Florence Janody Prin
Page 45 and 46: EPIGENETIC MECHANISMS Lars Jansen P
Page 47 and 48: SYSTEMS NEUROSCIENCE THIS GROUP IS
Page 49 and 50: PATTERNING AND MORPHOGENESIS Moisé
Page 51 and 52: EARLY FLY DEVELOPMENT Rui Gonçalo
Page 53 and 54: BEHAVIOURAL NEUROSCIENCE THIS GROUP
Page 55 and 56: DISEASE GENETICS Carlos Penha Gonç
Page 57 and 58: COMPUTATIONAL GENOMICS José Pereir
Page 59 and 60: COMPLEX ADAPTIVE SYSTEMS AND COMPUT
Page 61 and 62: hypothesis that expression of HO-1
Page 63 and 64: hemocyte purification using a combi
Page 65 and 66: EVOLUTIONARY GENETICS Henrique Teot
Page 67 and 68: BACTERIAL SIGNALLING Karina B. Xavi
Page 69 and 70: BIOPHYSICS AND GENETICS OF MORPHOGE
Page 71 and 72: PLANT GENOMICS Jörg Becker Researc
Page 73 and 74: NETWORK MODELLING Claudine Chaouiya
Page 75 and 76: NEURONAL STRUCTURE AND FUNCTION Inb
Page 77 and 78: NEUROETHOLOGY LABORATORY THIS GROUP
Page 79 and 80: LEARNING LABORATORY THIS GROUP IS A
Page 81 and 82: IMMUNE REGULATION Carlos E. Tadokor
Page 83 and 84: STRESS AND CYTOSKELETON Escola Supe
Page 85 and 86: ANIMAL FACILITIES Jocelyne Demengeo
Page 87 and 88: TRANSGENICS UNIT Moisés Mallo Head
Page 89 and 90: CELL IMAGING UNIT José Feijó Head
Page 91: GENOMICS UNIT Carlos Penha Gonçalv
Page 95 and 96: ION DYNAMICS FACILITY Ana Catarina
Page 97 and 98: BIOINFORMATICS AND COMPUTATIONAL BI
Page 99 and 100: PORTUGUESE BIOINFORMATICS CENTRE Pe
Page 101 and 102: INNOVATION AND TECHNOLOGY TRANSFER
Page 103 and 104: ADMINISTRATION AND ACCOUNTS José M
Page 105 and 106: NATIONAL AND INTERNATIONAL RESEARCH
Page 107 and 108: PUBLICATIONS IGC ANNUAL REPORT ‘1
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Page 119 and 120: IGC ANNUAL REPORT ‘11 PUBLICATION
Page 121 and 122: António Coutinho Professional Meri
Page 123 and 124: GRADUATE TRAINING AND EDUCATION
Page 125 and 126: Cells to organisms I 24 - 28 Octobe
Page 127 and 128: INDP - INTERNATIONAL NEUROSCIENCE D
Page 129 and 130: Extroduction 30 May - 3 June Organi
Page 131 and 132: PROGRAMME FOR ADVANCED MEDICAL RESE
Page 133 and 134: GTPB - THE GULBENKIAN TRAINING PROG
Page 135 and 136: THESES MSc THESES Sofia Pereira Dev
Page 137 and 138: SEMINARS AT THE IGC JANUARY 2011 DA
Page 139 and 140: MARCH 2011 DATE SPEAKER AFFILIATION
Page 141 and 142: MAY 2011 DATE SPEAKER AFFILIATION T
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JULY 2011 DATE SPEAKER AFFILIATION
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OCTOBER 2011 DATE SPEAKER AFFILIATI
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DECEMBER 2011 DATE SPEAKER AFFILIAT
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On the origin and diversification o
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HELENA COSTA Mechanism of IL-8 indu
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Of models and mechanisms of ion dyn
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The centromere: A showcase for epig
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Mechanisms determining adult body s
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The evolutionary dynamics of (Rab)
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HENRIQUE TEÓTONIO The genetic basi
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EMBnet - ANNUAL GENERAL MEETING 201
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PUBLIC ENGAGEMENT IN SCIENCE
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Science Projects Support Programme
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FUNDRAISING Maria João Leão Head
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PARTNERS AND SPONSORS Several partn
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