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Stage-based Interventions<br />
Early Recovery<br />
• Metabolic adverse effects<br />
– Monitor: weight, lipids, A1C<br />
– Prevent:<br />
§ Lifestyle counseling<br />
§ Pharmacological: Metformin 500 to 2000 mg daily<br />
• Hyperprolactinemia-related adverse effects<br />
(bone demineralization, hypogonadism)<br />
– Monitor<br />
§ Measure prolactin in risperidone, paliperidone, and typical<br />
antipsychotic treated patients<br />
– Prevent<br />
§ Pharmacological: aripiprazole, bromocriptine<br />
Ajmal A, et al. Psychosomatics. 2014;55:29-36; Kelly DL, et al. BMC Psychiatry. 2013;13:214; Mizuno Y, et al. Schizophrenia<br />
Bull. 2014;40:1385-1403.
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