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Suicide Attempts Increase<br />
When Therapy Is Interrupted<br />
100<br />
Suicide Attempt Rate/<br />
1000 person/y<br />
80<br />
60<br />
40<br />
20<br />
20<br />
72<br />
Age/gender-adjusted<br />
relative risk increased<br />
4.2 times (95% CI:<br />
1.7-10.1)<br />
0<br />
No Interruption<br />
n=399<br />
≥30-day Interruption<br />
n=204<br />
Data obtained from drug-dispensing and hospital discharge records (Netherlands) for<br />
schizophrenic patients (sample size, 603) in database (N=865,000) with drug interruption and<br />
≥30-day gap in treatment. Risk estimates were controlled for differences in age and gender.<br />
Herings RM, et al. Pharmacoepidemiol Drug Saf. 2003;112:423-424.
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