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Do Antipsychotics Contribute to Gray Matter Loss? Only treated with “atypical” antipsychotics, size of circle reflects relative sample size in study. clozapine olanzapine quetiapine risperidone ziprasidone multiple-atypicals P=0.003 Mean Daily Antipsychotic Dose Administered During Scan Interval (chlorpromazine equivalents) Image used with permission. Vita A, et al. Biol Psychiatry. 2015;78(6):403-412. 30
Outline • Adherence in Schizophrenia – Challenges of adherence in chronic illnesses – Strategies to improve adherence – Emerging therapies that may improve adherence – Emerging delivery and administration methods that may improve adherence
Page 1 and 2: Across the Spectrum: Managing First
Page 3 and 4: Diana O. Perkins, MD, MPH Professor
Page 5 and 6: Outline • Achieving Appropriate a
Page 7 and 8: When to Diagnose? Progressive Stage
Page 9 and 10: When to Diagnose? Progressive Stage
Page 11 and 12: How to Diagnose? Domains of Psychos
Page 13 and 14: Treatment of First-episode Schizoph
Page 15 and 16: Stage-based Interventions Early Rec
Page 17 and 18: N-Acetyl Cysteine: Clinical Trial
Page 19 and 20: L-Theanine: Clinical Trial • Rati
Page 21 and 22: Cariprazine: Clinical Trial • Rat
Page 23 and 24: Paliperidone Palmitate versus Place
Page 25 and 26: Meta-analysis: Relapse Rates First
Page 27 and 28: Are Some Patients Harmed by Antipsy
Page 29: Do Antipsychotics Contribute to Gra
Page 33 and 34: Clinical Consequences of Nonadheren
Page 35 and 36: Suicide Attempts Increase When Ther
Page 37 and 38: Unfortunately, We Overestimate Adhe
Page 39 and 40: Reverberations from Adverse Effects
Page 41 and 42: Long-acting Injectable Antipsychoti
Page 43 and 44: Impact of Collaborative Care • Re
Page 45 and 46: Choosing an Antipsychotic: Switch o

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