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When to Diagnose?<br />
Progressive Stages of Illness in Schizophrenia<br />
Premorbid<br />
Prodromal<br />
Onset/<br />
Deterioration<br />
Residual/Stable<br />
Healthy<br />
Margin of Prevention<br />
Worsening<br />
Severity of<br />
Signs and<br />
Symptoms<br />
Abnormal Brain<br />
Development<br />
Sensitization by dopamine (?)<br />
Excitatory neurotoxicity of glutamate (?)<br />
Neurochemical<br />
Dysregulation<br />
Neurodegeneration<br />
Gestation/Birth 10 Puberty 20 30 40 50<br />
Years<br />
Adapted from: Lieberman JA, et al. Biol Psychiatry. 2001;50(11):884-897.
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