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Hazard Ratio<br />
Stopping Medication Is the Most Powerful<br />
Predictor of First-episode Relapse<br />
6<br />
5<br />
4<br />
3<br />
2<br />
1<br />
0<br />
4.89<br />
First<br />
Relapse<br />
4.57<br />
Second<br />
Relapse<br />
Sample of 104 first-episode schizophrenia patients<br />
who responded to treatment of their index episode but<br />
were at risk for relapse.<br />
• Relapse risk is 5 times<br />
higher after a first-episode<br />
patient stops antipsychotic<br />
medication 1<br />
• Predictors of nonadherence<br />
in first year:<br />
– Early adolescent premorbid<br />
adjustment (P
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