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Meta-analysis: Relapse Rates<br />
First Generation versus Second Generation<br />
• Subjects: 23 studies, n=4504 with schizophrenia<br />
• Study duration: ≥3 months<br />
• Outcomes:<br />
• Risk of relapse higher in persons treated with first<br />
generation versus second generation<br />
antipsychotics (P=.0007), Number-needed-totreat<br />
= 17 (95% CI: 10-50)<br />
• Lower rates with second versus first generation:<br />
• Relapse at 3, 6, 12 months (P=.04, P
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